Impact of Obstructive Sleep Apnea and Current Treatments on the Development and Progression of Type 2 Diabetes

被引：7

作者：

Faria, Andre ^{[1
]}

Laher, Ismail ^{[2
]}

Fasipe, Babatunde ^{[3
]}

Ayas, Najib T. ^{[4
,5
]}

机构：

[1] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil

[2] Univ British Columbia, Fac Med, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC, Canada

[3] Bowen Univ, Fac Basic Clin Sci, Dept Pharmacol & Therapeut, Iwo, Nigeria

[4] Univ British Columbia, Div Crit Care, Vancouver, BC, Canada

[5] Univ British Columbia, Div Resp Med, Vancouver, BC, Canada

来源：

CURRENT DIABETES REVIEWS | 2022年 / 18卷 / 09期

关键词：

Obstructive sleep apnea; type; 2; diabetes; insulin resistance; treatments; CPAP; oral appliances; weight loss; POSITIVE AIRWAY PRESSURE; INTERMITTENT HYPOXIA; INSULIN-RESISTANCE; CONTROLLED-TRIAL; ADIPOSE-TISSUE; WEIGHT-LOSS; RISK-FACTOR; PREVALENCE; GLUCOSE; INFLAMMATION;

D O I：

10.2174/1573399818666220216095848

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus remains a growing health concern, affecting more than 420 million people globally. Preventing and treating diabetes require a better understanding of the associated risk factors. Sleep-disordered breathing, especially obstructive sleep apnea (OSA), is likely a contributor to the pathogenesis and aggravation of poor glycemic control. We review key epidemiological data that address the link between OSA and type 2 diabetes and present the current proposed pathophysiological mechanisms underlying this association. Several biological pathways are linking OSA and an increased propensity to diabetes. We review the impact of current treatment strategies for OSA based on the association between diabetes and sleep apnea.

引用

页码：25 / 32

页数：8

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