Tumor necrosis factor: An apoptosis JuNKie?

被引：423
作者：
Varfolomeev, EE [1 ]
Ashkenazi, A [1 ]
机构：
[1] Genentech Inc, San Francisco, CA 94080 USA
来源：
CELL | 2004年 / 116卷 / 04期
关键词：
D O I：
10.1016/S0092-8674(04)00166-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.
引用
收藏
页码：491 / 497
页数：7
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