Tumor necrosis factor: An apoptosis JuNKie?

被引：423

作者：

Varfolomeev, EE ^{[1
]}

Ashkenazi, A ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

CELL | 2004年 / 116卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(04)00166-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

引用

页码：491 / 497

页数：7

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