RETRACTED: HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway (Retracted Article)

被引：21
|
作者：
Yang, Guang [1 ]
Zhang, Min [2 ]
Zhao, Yawei [2 ]
Pan, Yue [2 ]
Kan, Mujie [3 ]
Li, Jing [2 ]
He, Kan [2 ]
Zhang, Xuewen [1 ]
机构：
[1] Jilin Univ, Affiliated Hosp 2, Dept Hepatobiliary & Pancreat Surg, Changchun, Jilin, Peoples R China
[2] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, Changchun, Peoples R China
[3] Jilin Univ, Dept Biochem, Coll Basic Med Sci, Changchun, Peoples R China
来源：
PLOS ONE | 2020年 / 15卷 / 03期
关键词：
EXPRESSION; MICRORNA-122;
D O I：
10.1371/journal.pone.0230450
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC development. In our study we showed that HNF-4 alpha and MiR-122 were down-regulated significantly in hepatocellular carcinoma. Over-expression of HNF-4 alpha inhibit hepatocellular carcinoma cells proliferation. And miR-122 is one of the down-stream effector of HNF-4 alpha. Up-regulated miR-122 inhibited hepatocellular carcinoma cells proliferation through regulating ADAM17. Collectively, our results suggested that HNF-4 alpha could inhibit hepatocellular carcinoma proliferation with miR-122 being a downstream target of it. And miR-122 would inhibit hepatocellular carcinoma proliferation by regulating ADAM17 signal pathway.
引用
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页数：10
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