Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons

被引：10
作者：
Chameh, Homeira Moradi [1 ]
Janahmadi, Mahyar [2 ,3 ]
Semnanian, Saeed [1 ]
Shojaei, Amir [1 ]
Mirnajafi-Zadeh, Javad [1 ]
机构：
[1] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran 1411713116, Iran
[2] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Fac Med, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Dept Physiol, Fac Med, Tehran, Iran
来源：
BRAIN RESEARCH | 2015年 / 1606卷
基金：
美国国家科学基金会;
关键词：
Electrophysiological properties; Kindling; Amygdala; Repetitive transcranial magnetic stimulation; Antiepileptogenic; REFRACTORY PARTIAL EPILEPSY; LONG-TERM POTENTIATION; HUMAN MOTOR CORTEX; MESSENGER-RNA; I-H; SYNAPTIC POTENTIATION; HIPPOCAMPAL-LESIONS; CORTICAL DYSPLASIA; FEBRILE SEIZURES; SODIUM-CHANNELS;
D O I：
10.1016/j.brainres.2015.02.023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, the effect of repetitive transcranial magnetic stimulation (rTMS) on the kindling induced changes in electrophysiological firing properties of hippocampal CA1 pyramidal neurons was investigated. Male Wistar rats were kindled by daily electrical stimulation of the basolateral amygdala in a semi-rapid manner (12 stimulations/day) until they achieved stage-5 seizure. One group (kindled+rTMS (KrTMS)) of animals received rTMS (240 pulses at 1 Hz) at 5 min after termination of daily kindling stimulations. Twenty-four hours following the last kindling stimulation electrophysiological properties of hippocampal CA1 pyramidal neurons were investigated using a whole-cell patch damp technique, under current clamp condition. Amygdala kindling significantly decreased the adaptation index, post-afterhyperpolarization, rheobase current, utilization time, and delay to the first rebound spike. It also caused an increase in the voltage sag, number of rebound spikes and number of evoked action potential. Results of the present study revealed that application of rTMS following kindling stimulations had antiepileptogenic effects. In addition, application of rTMS prevented hyperexcitability of CA1 pyramidal neurons induced by kindling and conserved the normal neuronal firing. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：34 / 43
页数：10
相关论文
共 86 条
[1]   Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats [J].
Akamatsu, N ;
Fueta, Y ;
Endo, Y ;
Matsunaga, K ;
Uozumi, T ;
Tsuji, S .
NEUROSCIENCE LETTERS, 2001, 310 (2-3) :153-156
[2]  
[Anonymous], 2013, RAT BRAIN STEREOTAXI
[3]   Anti-kindling effect of slow repetitive transcranial magnetic stimulation in rats [J].
Anschel, DJ ;
Pascual-Leone, A ;
Holmes, GL .
NEUROSCIENCE LETTERS, 2003, 351 (01) :9-12
[4]   INVIVO KINDLING DOES NOT ALTER AFTERHYPERPOLARIZATIONS (AHPS) FOLLOWING ACTION-POTENTIAL FIRING INVITRO IN BASOLATERAL AMYGDALA NEURONS [J].
ASPRODINI, EK ;
RAINNIE, DG ;
ANDERSON, AC ;
SHINNICKGALLAGHER, P .
BRAIN RESEARCH, 1992, 588 (02) :329-334
[5]   Safety and tolerability of repetitive transcranial magnetic stimulation in patients with epilepsy: a review of the literature [J].
Bae, Erica Hyunji ;
Schrader, Lara M. ;
Machii, Katsuyuki ;
Alonso-Alonso, Miguel ;
Riviello, James J., Jr. ;
Pascual-Leone, Alvaro ;
Rotenberg, Alexander .
EPILEPSY & BEHAVIOR, 2007, 10 (04) :521-528
[6]  
BARKER AT, 1985, LANCET, V1, P1106
[7]   Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus [J].
Bender, RA ;
Soleymani, SV ;
Brewster, AL ;
Nguyen, ST ;
Beck, H ;
Mathern, GW ;
Baram, TZ .
JOURNAL OF NEUROSCIENCE, 2003, 23 (17) :6826-6836
[8]   Human epilepsies: interaction of genetic and acquired factors [J].
Berkovic, Samuel F. ;
Mulley, John C. ;
Scheffer, Ingrid E. ;
Petrou, Steven .
TRENDS IN NEUROSCIENCES, 2006, 29 (07) :391-397
[9]   Hyperpolarization-Activated Cation Channels: From Genes to Function [J].
Biel, Martin ;
Wahl-Schott, Christian ;
Michalakis, Stylianos ;
Zong, Xiangang .
PHYSIOLOGICAL REVIEWS, 2009, 89 (03) :847-885
[10]   Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis [J].
Blumenfeld, Hal ;
Lampert, Angelika ;
Klein, Joshua P. ;
Mission, John ;
Chen, Michael C. ;
Rivera, Maritza ;
Dib-Hajj, Sulayman ;
Brennan, Avis R. ;
Hains, Bryan C. ;
Waxman, Stephen G. .
EPILEPSIA, 2009, 50 (01) :44-55
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