Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration

被引：91

作者：

Hayashi, Hisaki ^{[1
]}

Kume, Tsutomu ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 367卷 / 03期

关键词：

forkhead/fox proteins; Foxc1; Foxc2; CXCR4; CXCL12/SDF-1; migration; endothelial cells;

D O I：

10.1016/j.bbrc.2007.12.183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Foxc1 and Foxc2 transcription factors are required for vascular development. However, the molecular mechanisms by which Foxcl and Foxc2 control angiogenesis, the growth of new blood vessels from pre-existing vessels and capillaries, remain unknown. CXC chemokine ligand 12 (CXCL12) and its receptor, CXCR4, are critical for the process of angiogenesis, including the migration and tube formation of endothelial cells. Here we show that Foxcl and Foxc2 directly induce CXCR4 expression by activating its promoter in endothelial cells. Furthermore, Foxc1-deficient endothelial cells show a significant reduction in CXCR4 expression as well as CXCL12-stimulated migration. Taken together, these results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：584 / 589

页数：6

共 28 条

[21] Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1 [J].

Salvucci, O ;

Yao, L ;

Villalba, S ;

Sajewicz, A ;

Pittaluga, S ;

Tosato, G .

BLOOD, 2002, 99 (08) :2703-2711

[22] Regulation of the chemokine receptor CXCR4 by hypoxia [J].

Schioppa, T ;

Uranchimeg, B ;

Saccani, A ;

Biswas, SK ;

Doni, A ;

Rapisarda, A ;

Bernasconi, S ;

Saccani, S ;

Nebuloni, M ;

Vago, L ;

Mantovani, A ;

Melillo, G ;

Sica, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (09) :1391-1402

[23] The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development [J].

Seo, Seungwoon ;

Fujita, Hideo ;

Nakano, Atsushi ;

Kang, Myengmo ;

Duarte, Antonio ;

Kume, Tsutomu .

DEVELOPMENTAL BIOLOGY, 2006, 294 (02) :458-470

[24] The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract [J].

Tachibana, K ;

Hirota, S ;

Iizasa, H ;

Yoshida, H ;

Kawabata, K ;

Kataoka, Y ;

Kitamura, Y ;

Matsushima, K ;

Yoshida, N ;

Nishikawa, S ;

Kishimoto, T ;

Nagasawa, T .

NATURE, 1998, 393 (6685) :591-594

[25] Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1 [J].

Wegner, SA ;

Ehrenberg, PK ;

Chang, G ;

Dayhoff, DE ;

Sleeker, AL ;

Michael, NL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (08) :4754-4760

[26] Adrenomedullin/cyclic AMP pathway induces notch activation and differentiation of arterial endothelial cells from vascular progenitors [J].

Yurugi-Kobayashi, Takami ;

Itoh, Hiroshi ;

Schroeder, Timm ;

Nakano, Akiko ;

Narazaki, Genta ;

Kita, Fumiyo ;

Yanagi, Kentoku ;

Hiraoka-Kanie, Mina ;

Inoue, Emi ;

Ara, Toshiaki ;

Nagasawa, Takashi ;

Just, Ursula ;

Nakao, Kazuwa ;

Nishikawa, Shin-Ichi ;

Yamashita, Jun K. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (09) :1977-1984

[27] Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice [J].

Zhang, Huimin ;

Lawson, William E. ;

Polosukhin, Vasiliy V. ;

Pozzi, Ambra ;

Blackwell, Timothy S. ;

Litingtung, Ying ;

Chiang, Chin .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (04) :1113-1126

[28] Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development [J].

Zou, YR ;

Kottmann, AH ;

Kuroda, M ;

Taniuchi, I ;

Littman, DR .

NATURE, 1998, 393 (6685) :595-599

← 1 2 3 →