Chromosome Conformation Capture and Beyond: Toward an Integrative View of Chromosome Structure and Function

被引：127

作者：

McCord, Rachel Patton ^{[1
]}

Kaplan, Noam ^{[2
]}

Giorgetti, Luca ^{[3
]}

机构：

[1] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN USA

[2] Technion Israel Inst Technol, Rappaport Fac Med, Dept Physiol Biophys & Syst Biol, Haifa, Israel

[3] Friedrich Miescher Inst Biomed Res, Basel, Switzerland

来源：

MOLECULAR CELL | 2020年 / 77卷 / 04期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

HI-C REVEALS; TOPOLOGICALLY ASSOCIATING DOMAINS; SCALE CHROMATIN ORGANIZATION; NUCLEAR LAMINA INTERACTIONS; SPATIAL-ORGANIZATION; GENOME ORGANIZATION; GENE-EXPRESSION; HIGH-RESOLUTION; X-CHROMOSOME; REGULATORY LANDSCAPES;

D O I：

10.1016/j.molcel.2019.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapidly developing technologies have recently fueled an exciting era of discovery in the field of chromosome structure and nuclear organization. In addition to chromosome conformation capture (3C) methods, new alternative techniques have emerged to study genome architecture and biological processes in the nucleus, often in single or living cells. This sets an unprecedented stage for exploring the mechanisms that link chromosome structure and biological function. Here we review popular as well as emerging approaches to study chromosome organization, focusing on the contribution of complementary methodologies to our understanding of structures revealed by 3C methods and their biological implications, and discuss the next technical and conceptual frontiers.

引用

页码：688 / 708

页数：21

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