Graphene Oxide-loaded magnetic nanoparticles within 3D hydrogel form High-performance scaffolds for bone regeneration and tumour treatment

被引：51

作者：

Li, Yan ^{[1
]}

Huang, Lijing ^{[2
]}

Tai, Guangpin ^{[3
]}

Yan, Feifei ^{[4
]}

Cai, Lin ^{[4
]}

Xin, Chenxing ^{[1
]}

Al Islam, Shamoon ^{[1
]}

机构：

[1] China Univ Geosci, Gemmol Inst, Wuhan 430074, Peoples R China

[2] South China Univ Technol, Natl Engn Res Ctr Novel Equipment Polymer Proc, Key Lab Polymer Proc Engn, Minist Educ, Guangzhou 510640, Peoples R China

[3] Hefei Univ, Key Lab Biofabricat AnHui Higher Educ Inst, Ctr Adv Biofabricat, Hefei 230601, Peoples R China

[4] Wuhan Univ, Dept Spine Surg & Musculoskeletal Tumor, Zhongnan Hosp, Wuhan, Peoples R China

来源：

COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING | 2022年 / 152卷

基金：

中国国家自然科学基金;

关键词：

Graphene; Microstructural analysis; Thermal properties; 3-D printing; MECHANICAL-PROPERTIES; COMPOSITE SCAFFOLDS; IN-VITRO; TISSUE; FABRICATION; ALGINATE; BIOINK; NANOCOMPOSITES; CHONDROCYTES; POROSITY;

D O I：

10.1016/j.compositesa.2021.106672

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The treatment of tumour-related bone defects should ideally combine bone regeneration with tumour treatment. Additive manufacturing (AM) could feasibly place functional bone-repair materials within composite materials with functional-grade structures, giving them bone repair and anti-tumour effects. Magnetothermal therapy is a promising non-invasive method of tumour treatment that has attracted increasing attention. In this study, we prepared novel hydrogel composite scaffolds of polyvinyl alcohol/sodium alginate/hydroxyapatite (PVA/SA/ HA) at low temperature via AM. The scaffolds were loaded with various concentrations of magnetic graphene oxide (MGO) @Fe3O4 nanoparticles. The scaffolds were characterised by fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and thermal gravimetric analysis (TGA), which showed that the scaffolds have good moulding qualities and strong hydrogen bonding between the MGO/PVA/SA/HA components. TGA analysis demonstrated the expected thermal stability of the MGO and scaffolds. Thermal effects can be adjusted by varying the contents of MGO and the strength of an external alternating magnetic field. The prepared MGO hydrogel composite scaffolds enhance biological functions and support bone mesenchymal stem cell differentiation in vitro. The scaffolds also show favourable anti-tumour characteristics with effective magnetothermal conversion in vivo.

引用

页数：9