Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis

被引：53
|
作者：
Ming, Xin [1 ]
机构：
[1] Univ N Carolina, UNC Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA
来源：
EXPERT OPINION ON DRUG DELIVERY | 2011年 / 8卷 / 04期
关键词：
PEPTIDE NUCLEIC-ACID; IN-VIVO DELIVERY; SHORT INTERFERING RNA; TAT-FUSION PROTEINS; INTRACELLULAR DELIVERY; PENETRATING PEPTIDES; SCAVENGER RECEPTORS; TARGETED DELIVERY; MAMMALIAN-CELLS; LIVER-CELLS;
D O I：
10.1517/17425247.2011.561313
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Areas covered: This review provides an update on the progress of receptor-targeted delivery of oligonucleotides over the last 15 years and summarizes various targeting moieties for oligonucleotide delivery and coupling strategies. To inspire new strategies that can lead to oligonucleotides in the clinic, this review highlights how oligonucleotides successfully reach their intracellular targets by means of receptor-mediated endocytosis. Expert opinion: Understanding the mechanisms of oligonucleotide internalization has led to greater cellular uptake and superior endosomal release through the rational design of receptor-targeted delivery systems. Further improvements will again depend on a better understanding of the intracellular trafficking of oligonucleotides.
引用
收藏
页码：435 / 449
页数：15
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