Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner

被引：0

作者：

Berger, J. ^{[1
]}

Voigt, J. ^{[1
]}

Seifert, F. ^{[1
]}

Ebert, B. ^{[1
]}

Macdonald, R. ^{[1
]}

Gemeinhardt, I. ^{[2
]}

Gemeinhardt, O. ^{[3
]}

Schnorr, J. ^{[2
]}

Taupitz, M. ^{[2
]}

Vater, A. ^{[4
]}

Vollmer, S. ^{[4
]}

Licha, K. ^{[4
]}

Schirner, M. ^{[4
]}

机构：

[1] Charite Univ Med Berlin, Phys Tech Bundesanstalt, Abbestr 2-12, D-10587 Berlin, Germany

[2] Charite, Dept Radiol, Berlin, Germany

[3] Freie Univ, Inst Vet Anat, Fac Med Vet, Berlin, Germany

[4] Bayer Schering Pharma AG, Res Labs, Berlin, Germany

来源：

NOVEL OPTICAL INSTRUMENTATION FOR BIOMEDICAL APPLICATIONS III | 2007年 / 6631卷

关键词：

medical imaging; fluorescence imaging; laser-induced fluorescence; rheumatoid arthritis;

D O I：

10.1117/12.728307

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We have developed a flying-spot scanner for fluorescence imaging of rheumatoid arthritis in the near infrared (NIR) spectral range following intravenous administration of contrast agents. The new imaging system has been characterized with respect to linearity, dynamic range and spatial resolution with the help of fluorescent phantoms. In vivo experiments were performed on an animal model of rheumatoid arthritis. Finally, NIR-fluorescence images of early stages of joint inflammation have been compared with findings from contrast enhanced MR imaging and histology.

引用

页数：6