Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor

被引：66

作者：

Liu, Li ^{[1
,2
,3
,4
,5
]}

Nishihara, Reiko ^{[1
,2
,3
,6
,7
,8
]}

Qian, Zhi Rong ^{[1
,2
]}

Tabung, Fred K. ^{[3
,6
]}

Nevo, Daniel ^{[6
,7
]}

Zhang, Xuehong ^{[2
,9
]}

Song, Mingyang ^{[2
,3
,10
,11
]}

Cao, Yin ^{[2
,10
,11
]}

Mima, Kosuke ^{[1
,2
]}

Masugi, Yohei ^{[1
,2
]}

Shi, Yan ^{[1
,2
,12
]}

da Silva, Annacarolina ^{[1
,2
]}

Twombly, Tyler ^{[1
,2
]}

Gu, Mancang ^{[1
,2
,13
]}

Li, Wanwan ^{[1
,2
]}

Hamada, Tsuyoshi ^{[1
,2
]}

Kosumi, Keisuke ^{[1
,2
]}

Inamura, Kentaro ^{[14
]}

Nowak, Jonathan A. ^{[2
,8
]}

Drew, David A. ^{[2
,10
,11
]}

Lochhead, Paul ^{[2
,10
,11
]}

Nosho, Katsuhiko ^{[15
]}

Wu, Kana ^{[3
]}

Wang, Molin ^{[2
,6
,7
,8
]}

Garrett, Wendy S. ^{[16
,17
]}

Chan, Andrew T. ^{[2
,9
,10
,11
]}

Fuchs, Charles S. ^{[18
,19
,20
]}

Giovannucci, Edward L. ^{[2
,3
,6
,9
]}

Ogino, Shuji ^{[1
,2
,6
,8
,21
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA USA

[3] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[4] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China

[5] Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China

[6] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[7] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

[8] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02215 USA

[9] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02215 USA

[10] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA

[11] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA

[12] Chinese Peoples Liberat Army, Med Oncol Dept 2, Beijing, Peoples R China

[13] Zhejiang Chinese Med Univ, Coll Pharm, Hangzhou, Zhejiang, Peoples R China

[14] Japanese Fdn Canc Res, Canc Inst, Div Pathol, Tokyo, Japan

[15] Sapporo Med Univ, Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Hokkaido, Japan

[16] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA

[17] Massachusetts Inst Technol & Harvard, Broad Inst, Cambridge, MA USA

[18] Yale Canc Ctr, New Haven, CT USA

[19] Yale Sch Med, Dept Med, New Haven, CT USA

[20] Smilow Canc Hosp, New Haven, CT USA

[21] Dana Farber Canc Inst, Dept Oncol Pathol, Boston, MA 02115 USA

来源：

GASTROENTEROLOGY | 2017年 / 153卷 / 06期

基金：

北京市自然科学基金; 美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Adaptive Immune Cells; BRAF; CpG Island Methylator Phenotype; Cyclooxygenase-2; ISLAND METHYLATOR PHENOTYPE; MOLECULAR PATHOLOGICAL EPIDEMIOLOGY; MICROSATELLITE INSTABILITY; BRAF MUTATION; ASPIRIN USE; T-CELLS; CANCER; INDEX; PRECISION; CROSSTALK;

D O I：

10.1053/j.gastro.2017.08.045

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: Dietary patterns affect systemic and local intestinal inflammation, which have been linked to colorectal carcinogenesis. Chronic inflammation can interfere with the adaptive immune response. We investigated whether the association of a diet that promotes intestinal inflammation with risk of colorectal carcinoma was stronger for tumors with lower lymphocytic reactions than tumors with higher lymphocytic reactions. METHODS: We collected data from the molecular pathological epidemiology databases of 2 prospective cohort studies: the Nurses' Health Study (since 1976) and the Health Professionals Follow-Up Study (since 1986). We used duplication-method time-varying Cox proportional cause-specific hazards regression to assess the association of empirical dietary inflammatory pattern (EDIP) score (derived from food frequency questionnaire data) with colorectal carcinoma subtype. Foods that contribute to high EDIP scores include red and processed meats, refined grains, carbonated beverages, and some vegetables; foods that contribute to low EDIP scores include beer, wine, coffee, tea, yellow and leafy vegetables, and fruit juice. Colorectal tissue samples were analyzed histologically for patterns of lymphocytic reactions (Crohn's-like lymphoid reaction, peritumoral lymphocytic reaction, intratumoral periglandular reaction, and tumor-infiltrating lymphocytes). RESULTS: During follow-up of 124,433 participants, we documented 1311 incident colon and rectal cancer cases with available tissue data. The association between the EDIP and colorectal cancer risk was significant (P-trend = .02), and varied with degree of peritumoral lymphocytic reaction (P-heterogeneity < .001). Higher EDIP scores were associated with increased risk of colorectal cancer with an absent or low peritumoral lymphocytic reaction (highest vs lowest EDIP score quintile hazard ratio, 2.60; 95% confidence interval, 1.60 - 4.23; P-trend < .001), but not risk of tumors with intermediate or high peritumoral lymphocytic reaction (P-trend > .80). CONCLUSIONS: In 2 prospective cohort studies, we associated inflammatory diets with a higher risk of colorectal cancer subtype that contains little or no peritumoral lymphocytic reaction. These findings suggest that diet-related inflammation might contribute to development of colorectal cancer, by suppressing the adaptive anti-tumor immune response.

引用

页码：1517 / +

页数：28

共 67 条

[61] Functional properties of CD4+CD28- T cells in the aging immune system [J].