Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway

被引：46

作者：

Steigen, Sonja E. ^{[1
]}

Bjerkehagen, Bodil ^{[2
]}

Haugland, Hans K. ^{[3
]}

Nordrum, Ivar S. ^{[4
,5
]}

Loberg, Else Marit ^{[6
]}

Isaksen, Vidar ^{[1
]}

Eide, Tor J. ^{[2
]}

Nielsen, Torsten O. ^{[7
,8
]}

机构：

[1] Univ Tromso, Inst Med Biol, Dept Pathol, N-9037 Tromso, Norway

[2] Radiumhosp, Rikshosp, Med Ctr, Dept Pathol, Oslo, Norway

[3] Bergen Univ Hosp, Dept Pathol, Bergen, Norway

[4] Norwegian Univ Sci & Technol, Fac Med, Dept Lab Med Childrens & Womans Hlth, N-7034 Trondheim, Norway

[5] St Olavs Hosp, Dept Pathol & Med Genet, Trondheim, Norway

[6] Ullevaal Univ Hosp, Dept Pathol, Oslo, Norway

[7] Univ British Columbia, Dept Pathol, Vancouver, BC, Canada

[8] Univ British Columbia, Genet Pathol Evaluat Ctr, Vancouver, BC, Canada

来源：

MODERN PATHOLOGY | 2008年 / 21卷 / 01期

关键词：

gastrointestinal stromal tumors; CD117; antigen; prognostic markers; p16; L1;

D O I：

10.1038/modpathol.3800976

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract. The diagnosis of GIST is based on histology together with a panel of immunohistochemical markers; the most important is KIT (CD117). A total of 434 cases of GISTs were confirmed by histology and immunohistochemistry, and incorporated into tissue microarrays. Validation of histological features as well as the prognostic value of two immunohistochemical biomarkers (p16 and L1) was assessed. High mitotic rate, large tumor size, nuclear atypia, and small bowel primary site were all validated as negative prognostic factors in GISTs. Expression of p16 was significantly correlated with unfavorable prognosis, whereas L1 expression was not.

引用

页码：46 / 53

页数：8

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