Radioprotection of craniofacial bone growth

被引：1
作者：
Gevorgyan, Artur
La Scala, Giorgio C.
Neligan, Peter C.
Pang, Cho Y.
Forrest, Christopher R.
机构：
[1] Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada
[2] Hosp Sick Children, Div Plast Surg, Toronto, ON M5G 1X8, Canada
[3] Univ Geneva, Pediat Surg Clin, Childrens Hosp, Geneva, Switzerland
[4] Univ Hlth Network, Div Plast Surg, Toronto, ON, Canada
[5] Univ Toronto, Toronto, ON, Canada
来源：
JOURNAL OF CRANIOFACIAL SURGERY | 2007年 / 18卷 / 05期
关键词：
radiation; radiation-protective agents; Amifostine; bone development; osteoblasts;
D O I：
10.1097/scs.0b013e31812f7596
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
In this review, the potential of pharmacologic therapy for prevention of radiation-induced bone growth inhibition is discussed. Significant radioprotection using the radioprotector Amifostine has been achieved in animal models of radiation-induced retardation of long and craniofacial bone growth. Moreover, radioprotection in vitro has been achieved in a number of cell lines, including osteoblast-like, endothelial, and fibroblastic. This evidence may support future clinical investigations of radioprotector Amifostine or similar substances for radioprotection of the growing craniofacial skeleton.
引用
收藏
页码：995 / 1000
页数：6
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