Radioprotection of craniofacial bone growth

被引：1

作者：

Gevorgyan, Artur

La Scala, Giorgio C.

Neligan, Peter C.

Pang, Cho Y.

Forrest, Christopher R.

机构：

[1] Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Div Plast Surg, Toronto, ON M5G 1X8, Canada

[3] Univ Geneva, Pediat Surg Clin, Childrens Hosp, Geneva, Switzerland

[4] Univ Hlth Network, Div Plast Surg, Toronto, ON, Canada

[5] Univ Toronto, Toronto, ON, Canada

来源：

JOURNAL OF CRANIOFACIAL SURGERY | 2007年 / 18卷 / 05期

关键词：

radiation; radiation-protective agents; Amifostine; bone development; osteoblasts;

D O I：

10.1097/scs.0b013e31812f7596

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In this review, the potential of pharmacologic therapy for prevention of radiation-induced bone growth inhibition is discussed. Significant radioprotection using the radioprotector Amifostine has been achieved in animal models of radiation-induced retardation of long and craniofacial bone growth. Moreover, radioprotection in vitro has been achieved in a number of cell lines, including osteoblast-like, endothelial, and fibroblastic. This evidence may support future clinical investigations of radioprotector Amifostine or similar substances for radioprotection of the growing craniofacial skeleton.

引用

页码：995 / 1000

页数：6