One-pot synthesis of phthalides via regioselective intramolecular cyclization from ortho-alkynylbenzaldehydes

被引：20

作者：

Li, Jim ^{[1
]}

Chin, Elbert ^{[1
]}

Lui, Alfred S. ^{[1
]}

Chen, Lijing ^{[1
]}

机构：

[1] Roche Palo Alto, Dept Med Chem, Palo Alto, CA 94304 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 45期

关键词：

CARBOXYLIC-ACIDS; DERIVATIVES; OXIDATION; ALDEHYDES;

D O I：

10.1016/j.tetlet.2010.09.023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot synthesis of phthalides via an intramolecular 5-exo-dig cyclization of ortho-alkynylbenzaldehydes under mild NaClO2 oxidation conditions is described. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5937 / 5939

页数：3

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