Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility

被引：65
作者：
Curran, JE
Weinstein, SR
Griffiths, LR
机构：
[1] Griffith Univ Gold Coast, Sch Hlth Sci, Genom Res Ctr, Southport, Qld 9726, Australia
[2] Gold Coast Hosp, Dept Pathol, Southport, Qld, Australia
来源：
CANCER LETTERS | 2000年 / 153卷 / 1-2期
关键词：
polymorphism; glutathione S-transferases; susceptibility; sporadic breast cancer;
D O I：
10.1016/S0304-3835(00)00361-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The glutathione S-transferase (GST) family of enzymes function in the body to detoxify carcinogenic compounds. Several genes that code for these enzymes are polymorphic, with particular genotypes previously shown to confer an increased cancer risk. In this study, we investigated the role of three GST genes (GSTM1, GSTP1 and GSTT1) in the development of sporadic breast cancer. Genotypes were determined in 129 breast cancer affected and 129 age and sex matched control individuals. Results did not support an involvement of these specific GST gene polymorphisms, either independently or in combination, in susceptibility to sporadic breast cancer in the tested Australian Caucasian population. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.
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页码：113 / 120
页数：8
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