Antidyskinetic effect of magnesium sulfate in MPTP-lesioned monkeys

被引：8

作者：

Chassain, C ^{[1
]}

Eschalier, A ^{[1
]}

Durif, F ^{[1
]}

机构：

[1] INSERM, Unite EMI 9904, Fac Med & Pharm, F-63001 Clermont Ferrand, France

来源：

EXPERIMENTAL NEUROLOGY | 2003年 / 182卷 / 02期

关键词：

magnesium sulfate; antiparkinsonian effect; levodopa-induced dyskinesia; Parkinson's disease; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); monkeys;

D O I：

10.1016/S0014-4886(03)00125-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The antiparkinsonian action of an NMDA receptor antagonist, magnesium sulfate (50, 100, and 200 mg/kg), alone and in association with levodopa was explored in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian and control rhesus monkeys. At the three doses tested, magnesium sulfate decreased levodopa-induced dyskinesia [cumulative dyskinetic scores after levodopa: 129 +/- 13; after levodopa and magnesium sulfate: 65 +/- 14 (50 mg/kg), P < 0.001; 64 W (100 mg/kg), P < 0.001; 66 +/- 21 (200 mg/kg), P < 0.001, compared to levodopa administration alone]. These results show that magnesium sulfate importantly reduces levodopa-induced dyskinesia. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：490 / 496

页数：7

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