An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors

被引：25

作者：

Clement, Y ^{[1
]}

Kia, KH ^{[1
]}

Daval, G ^{[1
]}

Verge, D ^{[1
]}

机构：

[1] UNIV PARIS 06, URA CNRS 1488, INST NEUROSCI, F-75252 PARIS, FRANCE

来源：

BRAIN RESEARCH | 1996年 / 709卷 / 02期

关键词：

chromosome; open field; serotonin (5-HT); 5-HT1A; 5-HT1B; 5-HT2A; 5-HT2C; mapping;

D O I：

10.1016/0006-8993(95)01297-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modifications in serotonin (5-HT) neurotransmission have been associated with the physiopathology of anxiety and depression. Among the numerous 5-HT receptor subtypes, several (5-HT1A, 5-HT1B, 5-HT2 and 5-HT3) could be involved in these etiologies. By using a murine genetic model, we attempted to correlate variations in the density of receptor subtypes with modifications of anxiety-related behaviors. From a classic inbred strain (C57BL/6ByJ) and a linkage-testing inbred strain (ABP/Le), segregated F-2 populations for 3 loci located in the 4th, 7th and 9th chromosomes have been selected for their different responses in anxiety-related behavioral tests. The regional density of 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors has been measured in the brains of parental strains, F-1s and F-2 populations by quantitative autoradiography. The results suggest that chromosomal fragments containing the brown, pink-eyed dilution and the short-ear loci, previously shown to be involved in anxiogenic processes, are mainly associated with a variation in the density of the 5-HT1B receptors.

引用

页码：229 / 242

页数：14

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