Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review

被引：25

作者：

He, Jie ^{[1
]}

Qin, Man ^{[1
]}

Chen, Yingyi ^{[1
]}

Hu, Ziqi ^{[1
]}

Xie, Fei ^{[1
]}

Ye, Ling ^{[2
]}

Hui, Tianqian ^{[1
]}

机构：

[1] Peking Univ Sch & Hosp Stomatol, Dept Pediat Dent, 22 Zhongguancun South Ave, Beijing, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

来源：

CELL AND BIOSCIENCE | 2020年 / 10卷 / 01期

关键词：

Epigenetics; Matrix metalloproteinases; Inflammatory diseases; DNA methylation; Histone modification; microRNAs; LONG NONCODING RNA; DNA METHYLATION; HISTONE DEACETYLASES; OSTEOARTHRITIC CARTILAGE; SYNOVIAL FIBROBLASTS; ALTERED EXPRESSION; GENE-EXPRESSION; CPG SITES; MATRIX-METALLOPROTEINASE-9; DEMETHYLATION;

D O I：

10.1186/s13578-020-00451-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the metabolism of extracellular matrix (ECM). They play a key role in inflammation-related diseases. Factors such as inflammation, oxidative stress and growth factors stimulate the production of MMPs with subsequent ECM remodeling. Recently, the studies of epigenetic regulation, including the ability to predict disease progression, important pathophysiological deficiencies as well as treatment methods have been extensively discussed. This article reviews the current studies on epigenetic alterations in MMPs during inflammatory response. It is likely to provide new insights into development of efficient medications of epigenetic therapy for inflammatory diseases.

引用

页数：8

共 84 条

[1] MicroRNA-27b Regulates the Expression of Matrix Metalloproteinase 13 in Human Osteoarthritis Chondrocytes [J].