Ethylenediamine diacetate (EDDA)-catalyzed one-pot synthesis of tetrahydroquinolines by domino knoevenagel/hetero Diels-Alder reactions from 1,3-dicarbonyls

被引：54

作者：

Lee, Yong Rok ^{[1
]}

Hung, Thai Viet ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn & Technol, Gyongsan 712749, South Korea

来源：

TETRAHEDRON | 2008年 / 64卷 / 30-31期

关键词：

tetrahydroquinoline; knoevenagel/hetero Diels-Alder reaction; 1,3-dicarbonyis; aminobenzaldehydes;

D O I：

10.1016/j.tet.2008.05.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes new and efficient synthetic approaches for biologically interesting tetrahydroquirroline analogues. The key strategies involve the ethylenediamine diacetate-catalyzed cyclization of 1,3-dicarbonyls to aminobenzaldehydes through domino Knoevenagel/hetero Diels-Alder reactions. These reactions provide a rapid route for the synthesis of novel polycycles with the tetrahydroquinoline moiety. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：7338 / 7346

页数：9

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