Changes in lower urinary tract symptoms and quality of life after salvage radiotherapy for biochemical recurrence of prostate cancer

被引：13

作者：

Miyake, Makito ^{[1
]}

Tanaka, Nobumichi ^{[1
]}

Asakawa, Isao ^{[2
]}

Tatsumi, Yoshihiro ^{[1
,3
]}

Nakai, Yasushi ^{[1
]}

Anai, Satoshi ^{[1
]}

Torimoto, Kazumasa ^{[1
]}

Aoki, Katsuya ^{[1
]}

Yoneda, Tatsuo ^{[1
]}

Hasegawa, Masatoshi ^{[2
]}

Konishi, Noboru ^{[3
]}

Fujimoto, Kiyohide ^{[1
]}

机构：

[1] Nara Med Univ, Dept Urol, Nara 6348522, Japan

[2] Nara Med Univ, Dept Radiat Oncol, Nara 6348522, Japan

[3] Nara Med Univ, Dept Pathol, Nara 6348522, Japan

来源：

RADIOTHERAPY AND ONCOLOGY | 2015年 / 115卷 / 03期

关键词：

Prostate cancer; Salvage radiotherapy; International Prostate Symptom Score; Health-related quality of life; Disease-specific quality of life; SF-36; I-125 PERMANENT BRACHYTHERAPY; EXTERNAL-BEAM RADIOTHERAPY; RADICAL PROSTATECTOMY; RADIATION-THERAPY; HEALTH SURVEY; FOLLOW-UP; NARA; MEN; JAPAN; RELIABILITY;

D O I：

10.1016/j.radonc.2015.04.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: The aim of this study was to evaluate chronologic changes in lower urinary tract symptoms (LUTS), health-related (HR) quality of life (QOL), and disease-specific QOL during the first 12 months after salvage radiotherapy (SRT) for biochemical recurrence of prostate cancer in patients who underwent radical prostatectomy. Materials and methods: In 81 patients who received SRT (70 Gy/35fr/7 weeks), International Prostate Symptom Score (IPSS), 36-Item Short Form scores, and UCLA-Prostate Cancer Index (UCLA-PCI) were recorded before, during, and immediately after SRT, and 1-12 months after the completion of SRT. Results: The total IPSS and storage symptom-related sum were significantly increased following initiation of SRT, and returned to the baseline 6 months after SRT. For three of eight domains of HRQOL, and the physical component summary score showed transient deterioration in the period between completion of SRT and 1 month following SRT. The UCLA-PCI for urinary function/bother and bowel function/bother was affected until 1-6 months after SRT. Conclusions: This is the first report to concurrently evaluate detailed thronologic changes in LUTS and QOL in patients who received SRT. Knowledge of changes in LUTS and QOL outcomes associated with SRT may influence treatment recommendations and enable patients to make better-informed decisions. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：321 / 326

页数：6

共 29 条

[1] The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study [J].