Challenges and Opportunities for the Application of Boron Clusters in Drug Design

被引：254
作者：
Lesnikowski, Zbigniew J. [1 ]
机构：
[1] Polish Acad Sci, Inst Med Biol, Lab Mol Virol & Biol Chem, 106 Lodowa St, PL-93232 Lodz, Poland
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 59卷 / 17期
关键词：
NEUTRON-CAPTURE THERAPY; POTENTIAL DELIVERY AGENTS; NEUROPEPTIDE-Y ANALOGS; CARBORANYL OLIGONUCLEOTIDES; BIOLOGICAL EVALUATION; 3-DIMENSIONAL AROMATICITY; CARBABORANE DERIVATIVES; MEDICINAL CHEMISTRY; LABELED ANTIBODIES; ALKOXY DERIVATIVES;
D O I：
10.1021/acs.jmedchem.5b01932
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
There are two branches in boron medicinal chemistry: the first focuses on single boron atom compounds, and the second utilizes boron clusters. Boron clusters and their heteroatom counterparts belong to the family of cage compounds. A subset of this extensive class of compounds includes dicarbadodecaboranes, which have the general formula C2B10H12, and their metal biscarboranyl complexes, metallacarboranes, with the formula [M(C2B10H12)(2)(-2)]. The unique properties of boron clusters have resulted in their utilization in applications such as in pharmacophores, as scaffolds in molecular construction and as modulators of bioactive compounds. This perspective presents an overview of the properties of boron clusters that are pertinent for drug discovery, recent applications in the design of various classes of drugs and the potential use of boron clusters in the construction of new pharmaceuticals.
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收藏
页码：7738 / 7758
页数：21
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