Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker

被引：52
作者：
Danese, S. [1 ]
机构：
[1] IRCCS Gastroenterol, Div Gastroenterol, Ist Clin Humanitas, Viale Manzoni, Milan, Italy
来源：
DIGESTIVE AND LIVER DISEASE | 2008年 / 40卷
关键词：
Crohn's disease; Inflammatory bowel disease; Infliximab; Ulcerative colitis;
D O I：
10.1016/S1590-8658(08)60530-7
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a central role in mucosal inflammation and is a key mediator in the inflammatory cascade in both Crohn's disease (CD) and ulcerative colitis (UC). Infliximab, a monoclonal antibody against TNF-alpha has been proved highly effective in the clinical management of both forms of IBD. Aim of this paper is to review the mechanisms of action of infliximab in IBD. (c) 2008 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：S225 / S228
页数：4
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