Expression of cytokines IL-1β, IL-6 and TNF-α in intervertebral disc lesions of spinal tuberculosis

被引：0

作者：

Cao, Fujiang ^{[1
]}

Sun, Shiwei ^{[1
]}

Liu, Tao ^{[1
]}

Feng, Shiqing ^{[1
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Dept Orthoped, 154 Anshan Rd, Tianjin 300052, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Spinal tuberculosis; intervertebral disc lesions; expression of cytokines IL-1 beta; IL-6 and TNF-alpha; clinical significance; MUSCLE-FIBER CHANGES; POSTERIOR INSTRUMENTATION; RETROSPECTIVE ANALYSIS; KYPHOTIC DEFORMITY; MULTIFIDUS MUSCLE; ANTERIOR; FUSION; MODEL;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To investigate the gene expression of cytokines IL-1 beta, IL-6 and TNF-alpha in intervertebral disc lesions of spinal tuberculosis. Methods: Forty patients with spinal tuberculosis treated in our hospital from May 2014 to May 2016 were included in the spinal tuberculosis group, and other 40 patients with spinal disorders concurrently treated in our hospital were enrolled in the control group. With SPS 9001 kit, the expression levels of cytokines IL-1 beta, IL-6 and TNF-alpha of the two groups were examined using the enzyme linked immunosorbent assay (ELISA), and then statistical analyses were performed. Results: The levels of cytokines IL-1 beta, IL-6 and TNF-alpha levels among the patients in the spinal tuberculosis group (0.385 +/- 0.091 pg/ml, 0.378 +/- 0.097 pg/ml, 0.276 +/- 0.052) pg/ml, respectively) were significantly higher than those in the control group (0.190 +/- 0.066 pg/ml, 0.177 +/- 0.058 pg/ml, 0.147 +/- 0.043 pg/ml, respectively) (P< 0.05). Conclusion: The levels of cytokines IL-1 beta, IL-6 and TNF-alpha in intervertebral disc lesions of spinal tuberculosis were upregulated, which is worthy of clinical notice.

引用

页码：13201 / 13206

页数：6

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