Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation

被引：19

作者：

Amoni, Matthew ^{[1
,2
]}

Claus, Piet ^{[3
]}

Dries, Eef ^{[1
]}

Nagaraju, Chandan ^{[1
]}

De Buck, Stijn ^{[4
]}

Vandenberk, Bert ^{[2
]}

Ingelaere, Sebastian ^{[1
,2
]}

Vermoortele, Dylan ^{[3
]}

Roderick, H. Llewelyn ^{[1
]}

Sipido, Karin R. ^{[1
]}

Willems, Rik ^{[1
,2
]}

机构：

[1] Katholieke Univ Leuven, Dept Cardiovasc Sci, Expt Cardiol, Leuven, Belgium

[2] Univ Hosp Leuven, Div Cardiol, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Cardiovasc Sci, Imaging & Cardiovasc Dynam, Leuven, Belgium

[4] Katholieke Univ Leuven, Dept Elect Engn, Proc Speech & Images, Leuven, Belgium

来源：

HEART RHYTHM | 2021年 / 18卷 / 11期

关键词：

KEYWORDS Action potential; Delayed afterdepolarization; Myocar-; ventricular complex; ABLATION; ARRHYTHMIAS; ARRHYTHMOGENESIS;

D O I：

10.1016/j.hrthm.2021.07.067

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Sympathetic activation in ischemic heart disease can cause lethal arrhythmias. These often are preceded by premature ventricular complexes (PVCs), which at the cellular level could result from delayed afterdepolarizations. OBJECTIVE The purpose of this study was to identify and map vulnerable areas for arrhythmia initiation after myocardial infarction (MI) and to explore the link between PVCs and cellular events. METHODS Anterior-septal wall MI was induced by 120 minutes of coronary occlusion followed by reperfusion (27 MI and 16 sham pigs). After 4 weeks, EnSiteTM electroanatomic mapping combined with imaging was performed to precisely locate PVC sites of origin and subsequently record monophasic action potentials. Cardiomyocytes were isolated from different regions to study regional cellular remodeling. Isoproterenol was used as a surrogate for adrenergic stimulation both in vivo and in cardiomyocytes. RESULTS PVCs originated from the MI border zone (BZ) and

引用

页码：1976 / 1987

页数：12

共 25 条

[1] Acetylcholine Suppresses Ventricular Arrhythmias and Improves Conduction and Connexin-43 Properties During Myocardial Ischemia in Isolated Rabbit Hearts [J].

Aiba, Takeshi ;

Noda, Takashi ;

Hidaka, Ichiro ;

Inagaki, Masashi ;

Katare, Rajesh G. ;

Ando, Motonori ;

Sunagawa, Kenji ;

Sato, Takayuki ;

Sugimachi, Masaru .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2015, 26 (06) :678-685

[2] Focal myocardial infarction induces global remodeling of cardiac sympathetic innervation: neural remodeling in a spatial context [J].

Ajijola, Olujimi A. ;

Yagishita, Daigo ;

Patel, Krishan J. ;

Vaseghi, Marmar ;

Zhou, Wei ;

Yamakawa, Kentaro ;

So, Eileen ;

Lux, Robert L. ;

Mahajan, Aman ;

Shivkumar, Kalyanam .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2013, 305 (07) :H1031-H1040

[3] Shortened Ca2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death [J].

Belevych, Andriy E. ;

Terentyev, Dmitry ;

Terentyeva, Radmila ;

Ho, Hsiang-Ting ;

Gyorke, Inna ;

Bonilla, Ingrid M. ;

Carnes, Cynthia A. ;

Billman, George E. ;

Gyoerke, Sandor .

CIRCULATION RESEARCH, 2012, 110 (04) :569-U161

[4] Relationship of frequent postinfarction premature ventricular complexes to the reentry circuit of scar-related ventricular tachycardia [J].

Bogun, Frank ;

Crawford, Thomas ;

Chalfoun, Nagib ;

Kuhne, Micha ;

Sarrazin, Jean Francois ;

Wells, Darryl ;

Good, Eric ;

Jongnarangsin, Krit ;

Oral, Hakan ;

Chugh, Aman ;

Pelosi, Frank ;

Morady, Fred .

HEART RHYTHM, 2008, 5 (03) :367-374

[5] Subcutaneous nerve activity and spontaneous ventricular arrhythmias in ambulatory dogs [J].

Doytchinova, Anisiia ;

Patel, Jheel ;

Zhou, Shengmei ;

Chen, Lan S. ;

Lin, Hongbo ;

Shen, Changyu ;

Everett, Thomas H. ;

Lin, Shien-Fong ;

Chen, Peng-Sheng .

HEART RHYTHM, 2015, 12 (03) :612-620

[6] Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability [J].

Dries, Eef ;

Amoni, Matthew ;

Vandenberk, Bert ;

Johnson, Daniel M. ;

Gilbert, Guillaume ;

Nagaraju, Chandan K. ;

Puertas, Rosa Donate ;

Abdesselem, Mouna ;

Santiago, Demetrio J. ;

Roderick, H. Llewelyn ;

Claus, Piet ;

Willems, Rik ;

Sipido, Karin R. .

JOURNAL OF PHYSIOLOGY-LONDON, 2020, 598 (14) :2875-2895

[7] Cardiac three-dimensional magnetic resonance imaging and fluoroscopy merging -: A new approach for electroanatomic mapping to assist catheter ablation [J].

Ector, J ;

De Buck, S ;

Adams, J ;

Dymarkowski, S ;

Bogaert, J ;

Maes, F ;

Heidbüchel, H .

CIRCULATION, 2005, 112 (24) :3769-3776

[8] Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis [J].

Frisk, Michael ;

Ruud, Marianne ;

Espe, Emil K. S. ;

Aronsen, Jan Magnus ;

Roe, Asmund T. ;

Zhang, Lili ;

Norseng, Per Andreas ;

Sejersted, Ole M. ;

Christensen, Geir A. ;

Sjaastad, Ivar ;

Louch, William E. .

CARDIOVASCULAR RESEARCH, 2016, 112 (01) :443-451

[9]

GARDNER R, 2015, NAT COMMUN, V6, P1

[10] Ventricular arrhythmias and the His-Purkinje system [J].

Haissaguerre, Michel ;

Vigmond, Edward ;

Stuyvers, Bruno ;

Hocini, Meleze ;

Bernus, Olivier .

NATURE REVIEWS CARDIOLOGY, 2016, 13 (03) :155-166

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