Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes

被引：38

作者：

Zheng, Yan-Long ^{[1
,2
]}

Liu, Yan-Yao ^{[1
,2
]}

Wu, Yi-Mei ^{[1
,2
]}

Wang, Yin-Xia ^{[1
,2
]}

Lin, Yu-Tong ^{[1
,2
]}

Ye, Mengchun ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 21期

基金：

中国国家自然科学基金;

关键词：

aldehydes; alkenes; hydride transfer; iron; transfer hydrogenative couplings; C BOND FORMATION; ASYMMETRIC HYDROGENATION; H FUNCTIONALIZATION; CARBONYL ALLYLATION; NICKEL; OLEFINS; ACID; CYCLIZATION; 1,3-DIENES; RUTHENIUM;

D O I：

10.1002/anie.201602130

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An FeBr3-catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With (PrOH)-Pr-i as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and alpha-olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity.

引用

页码：6315 / 6318

页数：4

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