Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

被引：231
作者：
Miller, Stephen D. [1 ]
Turley, Danielle M. [1 ]
Podojil, Joseph R. [1 ]
机构：
[1] Northwestern Univ, Immunobiol Ctr, Dept Microbiol Immunol & Interdepartmental, Feinberg Sch Med, Chicago, IL 60611 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 09期
关键词：
D O I：
10.1038/nri2153
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.
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收藏
页码：665 / 677
页数：13
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