Vedolizumab-associated pulmonary manifestations in children with ulcerative colitis

被引：5

作者：

Cucinotta, Ugo ^{[1
]}

Dipasquale, Valeria ^{[1
]}

Costa, Stefano ^{[1
]}

Pellegrino, Salvatore ^{[1
]}

Ramistella, Vincenzo ^{[1
]}

Romano, Claudio ^{[1
]}

机构：

[1] Univ Messina, Dept Human Pathol Adulthood & Childhood G Barresi, Pediat Gastroenterol & Cyst Fibrosis Unit, I-98124 Messina, Italy

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2022年 / 47卷 / 02期

关键词：

adverse effects; children; inflammatory bowel disease; respiratory tract infection; ulcerative colitis; vedolizumab; INFLAMMATORY-BOWEL-DISEASE; MAINTENANCE THERAPY; EXPERIENCE; INDUCTION;

D O I：

10.1111/jcpt.13494

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and Objective The off-label use of vedolizumab (VDZ) for inflammatory bowel disease in children is increasing. We report on possibly the first case of VDZ-associated pulmonary manifestations in paediatrics. Case summary This report details the case of a 13-year-old child with ulcerative colitis who was initiated on VDZ due to persistent active disease. After the first three doses, he developed a persistent and productive cough. Microbiological work-up was normal. VDZ discontinuation led to the resolution of symptoms. What is new and conclusion To our knowledge, this is the first case report of VDZ-associated pulmonary manifestations in paediatrics. A direct, pro-inflammatory effect of VDZ has been hypothesized, but further studies are warranted.

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收藏

页码：254 / 256

页数：3

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