Axitinib for the treatment of patients with advanced metastatic renal cell carcinoma (mRCC) after failure of prior systemic treatment

被引：22
作者：
Gruenwald, Viktor [1 ]
Merseburger, Axel S. [2 ]
机构：
[1] Hannover Med Sch, Clin Hematol Hemostasis Oncol & Stem Cell Transpl, D-30625 Hannover, Germany
[2] Hannover Med Sch, Dept Urol, D-3000 Hannover, Germany
来源：
ONCOTARGETS AND THERAPY | 2012年 / 5卷
关键词：
tyrosine kinase inhibitor; axitinib; tivozanib; renal cell carcinoma; VEGF; PROGRESSION-FREE SURVIVAL; ADVANCED SOLID TUMORS; INTERFERON-ALPHA; PHASE-I; CANCER; BIOMARKER; EVEROLIMUS; SORAFENIB; INHIBITOR; SUNITINIB;
D O I：
10.2147/OTT.S23273
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The landscape of renal cell carcinoma (RCC) treatment has changed dramatically during recent years. Bevacizumab/interferon, sunitinib, sorafenib, temsirolimus, everolimus, and pazopanib have been proven effective in metastatic RCC. Axitinib is a novel tyrosine kinase inhibitor, which inhibits the vascular endothelial growth factor receptor (VEGFR) at subnanomolar level. Based on this extraordinary VEGFR inhibition, axitinib is considered a next-generation agent. The recent AXIS trial reported on axitinib's efficacy in second line treatment of RCC, which led to its recent approval in the USA. This review focuses on the clinical efficacy of axitinib in RCC patients.
引用
收藏
页码：111 / 117
页数：7
相关论文
共 43 条
[1]   A Phase 2 Study With a Daily Regimen of the Oral mTOR Inhibitor RAD001 (Everolimus) in Patients With Metastatic Clear Cell Renal Cell Cancer [J].
Amato, Robert J. ;
Jac, Jaroslaw ;
Giessinger, Sarah ;
Saxena, Somyata ;
Willis, James P. .
CANCER, 2009, 115 (11) :2438-2446
[2]  
[Anonymous], J CLIN ONCOL S
[3]   Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics [J].
Brennan, Meghan ;
Williams, J. Andrew ;
Chen, Ying ;
Tortorici, Michael ;
Pithavala, Yazdi ;
Liu, Yingxue Cathy .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 68 (05) :645-655
[4]   Sequence Therapy in Patients with Metastatic Renal Cell Carcinoma: Comparison of Common Targeted Treatment Options Following Failure of Receptor Tyrosine Kinase Inhibitors [J].
Busch, Jonas ;
Seidel, Christoph ;
Kempkensteffen, Carsten ;
Johannsen, Manfred ;
Wolff, Ingmar ;
Hinz, Stefan ;
Magheli, Ahmed ;
Miller, Kurt ;
Gruenwald, Viktor ;
Weikert, Steffen .
EUROPEAN UROLOGY, 2011, 60 (06) :1163-1170
[5]   Intrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma [J].
Busch, Jonas ;
Seidel, Christoph ;
Weikert, Steffen ;
Wolff, Ingmar ;
Kempkensteffen, Carsten ;
Weinkauf, Lisa ;
Hinz, Stefan ;
Magheli, Ahmed ;
Miller, Kurt ;
Gruenwald, Viktor .
BMC CANCER, 2011, 11
[6]   Sunitinib: From rational design to clinical efficacy [J].
Chow, Laura Q. M. ;
Eckhardt, S. Gail .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (07) :884-896
[7]   Targeted therapy for advanced renal cell cancer (RCC): a Cochrane systematic review of published randomised trials [J].
Coppin, Chris ;
Kollmannsberger, Christian ;
Le, Lyly ;
Porzsolt, Franz ;
Wilt, Timothy J. .
BJU INTERNATIONAL, 2011, 108 (10) :1556-1563
[8]   Phase II Study of Sorafenib in Patients With Sunitinib-Refractory Metastatic Renal Cell Cancer [J].
Di Lorenzo, Giuseppe ;
Carteni, Giacomo ;
Autorino, Riccardo ;
Bruni, Gianni ;
Tudini, Marianna ;
Rizzo, Mimma ;
Aieta, Michele ;
Gonnella, Antonio ;
Rescigno, Pasquale ;
Perdona, Sisto ;
Giannarini, Gianluca ;
Pignata, Sandro ;
Longo, Nicola ;
Palmieri, Giovannella ;
Imbimbo, Ciro ;
De Laurentiis, Michele ;
Mirone, Vincenzo ;
Ficorella, Corrado ;
De Placido, Sabino .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (27) :4469-4474
[9]  
Escudier B, 2011, EUR J CANC S, V47
[10]   Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial [J].
Escudier, Bernard ;
Pluzanska, Anna ;
Koralewski, Piotr ;
Ravaud, Alain ;
Bracarda, Sergio ;
Szczylik, Cezary ;
Chevreau, Christine ;
Filipek, Marek ;
Melichar, Bohuslav ;
Bajetta, Emilio ;
Gorbunova, Vera ;
Bay, Jacques-Olivier ;
Bodrogi, Istvan ;
Jagiello-Gruszfeld, Agnieszka ;
Moore, Nicola .
LANCET, 2007, 370 (9605) :2103-2111
12345