The Molecular Characterization of Virulence Determinants and Antibiotic Resistance Patterns in Human Bacterial Uropathogens

被引：20

作者：

Ahmed, Naveed ^{[1
,2
]}

Khalid, Hira ^{[3
]}

Mushtaq, Mariam ^{[3
]}

Basha, Sakeenabi ^{[4
]}

Rabaan, Ali A. ^{[5
,6
,7
]}

Garout, Mohammed ^{[8
]}

Halwani, Muhammad A. ^{[9
]}

Al Mutair, Abbas ^{[10
,11
,12
]}

Alhumaid, Saad ^{[13
]}

Al Alawi, Zainab ^{[14
]}

Yean, Chan Yean ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Med Microbiol & Parasitol, Kubang Kerian 16150, Kelantan, Malaysia

[2] Univ Cent Punjab, Fac Life Sci, Dept Microbiol, Lahore 54000, Punjab, Pakistan

[3] King Edward Med Univ, Dept Med Educ, Lahore 54000, Punjab, Pakistan

[4] Taif Univ, Fac Dent, Dept Community Dent, POB 11099, At Taif 21944, Saudi Arabia

[5] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran 31311, Saudi Arabia

[6] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia

[7] Univ Haripur, Dept Publ Hlth & Nutr, Haripur 22610, Khyber Pakhtunk, Pakistan

[8] Umm Al Qura Univ, Fac Med, Dept Community Med & Hlth Care Pilgrims, Mecca 21955, Saudi Arabia

[9] Al Baha Univ, Fac Med, Dept Med Microbiol, Al Baha 4781, Saudi Arabia

[10] Almoosa Specialist Hosp, Res Ctr, Al Hasa 36342, Saudi Arabia

[11] Princess Norah Bint Abdulrahman Univ, Coll Nursing, Riyadh 11564, Saudi Arabia

[12] Wollongong Univ, Sch Nursing, Wollongong, NSW 2522, Australia

[13] Minist Hlth, Al Ahsa Hlth Cluster, Adm Pharmaceut Care, Al Hasa 31982, Saudi Arabia

[14] King Faisal Univ, Coll Med, Div Allergy & Immunol, Al Hasa 31982, Saudi Arabia

来源：

ANTIBIOTICS-BASEL | 2022年 / 11卷 / 04期

关键词：

MRSA; XDR; antimicrobial resistance; antibiotic stewardship; virulence; UTIs; METALLO-BETA-LACTAMASES; PSEUDOMONAS-AERUGINOSA; ASYMPTOMATIC BACTERIURIA; PREVALENCE; LAHORE;

D O I：

10.3390/antibiotics11040516

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The high rates of bacterial infections affect the economy worldwide by contributing to the increase in morbidity and treatment costs. The present cross-sectional study was carried out to evaluate the prevalence of bacterial infection in urinary tract infection (UTI) patients and to evaluate the antimicrobial resistance rate (AMR) in a Tertiary Care Hospital in Lahore, Pakistan. The study was conducted for the period of one year from January 2020 to December 2020. A total of 1899 different clinical samples were collected and examined for bacterial cultures using standard procedures. Samples were inoculated on different culture media to isolate bacterial isolates and for identification and susceptibility testing. A total of 1107/1899 clinical samples were positive for Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli) and other bacterial isolates. Methicillin-resistant S. aureus (MRSA) prevalence was 16.93% from these positive cases. MRSA strains were found to be highly resistant to amikacin, clindamycin, fusidic acid, gentamicin and tobramycin, while highest sensitivity was noted against vancomycin (100%) and linezolid (100%). MRSA and high rates of multidrug resistance (MDR) pose a serious therapeutic burden to critically ill patients. A systematic and concerted effort is essential to rapidly identify high-risk patients and to reduce the burden of AMR.

引用

页数：11

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