Reduced volume of limbic system-affiliated basal ganglia in mood disorders: Preliminary data from a postmortem study

被引：153

作者：

Baumann, B ^{[1
]}

Danos, P ^{[1
]}

Krell, D ^{[1
]}

Diekmann, S ^{[1
]}

Leschinger, A ^{[1
]}

Stauch, R ^{[1
]}

Wurthmann, C ^{[1
]}

Bernstein, HG ^{[1
]}

Bogerts, B ^{[1
]}

机构：

[1] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1176/jnp.11.1.71

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Volumes of basal ganglia in postmortem brains of 8 patients with mood disorders and 8 control subjects without neuropsychiatric disorder were determined. Morphometry of serial whole-brain sections under the control of postmortem artifacts revealed reduced volumes of the left nucleus accumbens (-32%, P = 0.01), the right and left external pallidum (-20%, P = 0.04), and the right putamen (-15%, P = 0.04) in the patient group compared with the control group. These results suggest that, in particular, the limbic loop of the basal ganglia involving the nucleus accumbens and the pallidum is affected in mood disorders.

引用

页码：71 / 78

页数：8

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