Autoinflammation by Endogenous DNA

被引：22

作者：

Nagata, Shigekazu ^{[1
,2
]}

Kawane, Kohki ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto, Japan

[2] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kyoto, Japan

来源：

ADVANCES IN IMMUNOLOGY, VOL 110 | 2011年 / 110卷

关键词：

CASPASE-ACTIVATED DNASE; PROGRAMMED CELL-DEATH; INNATE IMMUNE-RESPONSE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INDEPENDENT GENE INDUCTION; AICARDI-GOUTIERES-SYNDROME; RED-BLOOD-CELLS; MOUSE EYE LENS; APOPTOTIC CELLS; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/B978-0-12-387663-8.00004-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In various mammalian developmental processes such as programmed cell death, erythropoiesis, and lens-cell differentiation, chromosomal DNA is degraded into nucleotides by a set of specific nucleases. If this process does not proceed smoothly, the undigested DNA causes various problems. For example, when chromosomal DNA is not degraded in the lens cells, cataracts form. In other cases, undigested DNA in macrophages activates the innate immune system, like a DNA virus, and causes strong inflammation, resulting in anemia, arthritis, and lymphopenia. Here, we discuss when, where, and how DNA is degraded to maintain mammalian homeostasis.

引用

收藏

页码：139 / 161

页数：23

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