Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice

被引：7

作者：

Hsu, Charlie C. ^{[1
]}

Meeker, Stacey M. ^{[1
]}

Escobar, Sabine ^{[1
]}

Brabb, Thea L. ^{[1
]}

Paik, Jisun ^{[1
]}

Park, Heon ^{[1
]}

Iritani, Brian M. ^{[1
]}

Maggio-Price, Lillian ^{[1
]}

机构：

[1] Univ Washington, Dept Comparat Med, Seattle, WA 98195 USA

来源：

VIROLOGY | 2018年 / 515卷

关键词：

Norovirus; Murine norovirus; Calicivirus; B cells; B lymphocytes; Statl; MURINE-NOROVIRUS-1; INFECTION; VIRUS-REPLICATION; CHEMOKINE CXCL12; INTERFERON; STAT1; LYMPHOPOIESIS; INFLAMMATION; DISEASE; ALPHA/BETA; GASTROENTERITIS;

D O I：

10.1016/j.virol.2017.12.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1(-/-) hematopoietic cells and Stat1(-/-) stromal cells, and that the presence of wild-type hematopoietic or stromal cells was sufficient to restore normal development of Stat1(-/-) B cells. These results suggest that B cells normally restrain norovirus replication in a cell autonomous manner, and that wild type STAT1 is required to protect B cell development during infection.

引用

页码：123 / 133

页数：11

共 55 条

[1] Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis [J].

Ahmed, Sharia M. ;

Hall, Aron J. ;

Robinson, Anne E. ;

Verhoef, Linda ;

Premkumar, Prasanna ;

Parashar, Umesh D. ;

Koopmans, Marion ;

Lopman, Benjamin A. .

LANCET INFECTIOUS DISEASES, 2014, 14 (08) :725-730

[2] Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: Consequences for virus replication in the presence of alpha/beta and gamma interferons [J].

Andrejeva, J ;

Young, DF ;

Goodbourn, S ;

Randall, RE .

JOURNAL OF VIROLOGY, 2002, 76 (05) :2159-2167

[3] THE CLINICAL SPECTRUM OF PATIENTS WITH DEFICIENCY OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION-1 [J].

Averbuch, Diana ;

Chapgier, Ariane ;

Boisson-Dupuis, Stephanie ;

Casanova, Jean-Laurent ;

Engelhard, Dan .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (04) :352-355

[4] Norovirus Regulation by Host and Microbe [J].

Baldridge, Megan T. ;

Turula, Holly ;

Wobus, Christiane E. .

TRENDS IN MOLECULAR MEDICINE, 2016, 22 (12) :1047-1059

[5] Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection [J].

Baldridge, Megan T. ;

Nice, Timothy J. ;

McCune, Broc T. ;

Yokoyama, Christine C. ;

Kambal, Amal ;

Wheadon, Michael ;

Diamond, Michael S. ;

Ivanova, Yulia ;

Artyomov, Maxim ;

Virgin, Herbert W. .

SCIENCE, 2015, 347 (6219) :266-269

[6] Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice [J].

Basic, Marijana ;

Keubler, Lydia M. ;

Buettner, Manuela ;

Achard, Marcel ;

Breves, Gerhard ;

Schroeder, Bernd ;

Smoczek, Anna ;

Joerns, Anne ;

Wedekind, Dirk ;

Zschemisch, Nils H. ;

Guenther, Claudia ;

Neumann, Detlef ;

Lienenklaus, Stefan ;

Weiss, Siegfried ;

Hornef, Mathias W. ;

Maehler, Michael ;

Bleich, Andre .

INFLAMMATORY BOWEL DISEASES, 2014, 20 (03) :431-443

[7] The burden of norovirus gastroenteritis: an important foodborne and healthcare-related infection [J].

Belliot, G. ;

Lopman, B. A. ;

Ambert-Balay, K. ;

Pothier, P. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (08) :724-730

[8] Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes [J].

Boisson-Dupuis, Stephanie ;

Kong, Xiao-Fei ;

Okada, Satoshi ;

Cypowyj, Sophie ;

Puel, Anne ;

Abel, Laurent ;

Casanova, Jean-Laurent .

CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (04) :364-378

[9] Apoptosis in Murine Norovirus-Infected RAW264.7 Cells Is Associated with Downregulation of Survivin [J].

Bok, Karin ;

Prikhodko, Victor G. ;

Green, Kim Y. ;

Sosnovtsev, Stanislav V. .

JOURNAL OF VIROLOGY, 2009, 83 (08) :3647-3656

[10] Effects of Acute and Chronic Inflammation on B-Cell Development and Differentiation [J].

Cain, Derek ;

Kondo, Motonari ;

Chen, Huaiyong ;

Kelsoe, Garnett .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (02) :266-277

← 1 2 3 4 5 6 →