Protein adsorption on blood-contact membranes

被引：153

作者：

Sun, SD ^{[1
]}

Yue, YL ^{[1
]}

Huang, XH ^{[1
]}

Meng, DY ^{[1
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, Dept Biomed Polymers & Artificial Organs, Chengdu 610065, Sichuan, Peoples R China

来源：

JOURNAL OF MEMBRANE SCIENCE | 2003年 / 222卷 / 1-2期

关键词：

blood-contact membranes; protein adsorption; fouling; affecting factor; surface modification;

D O I：

10.1016/S0376-7388(03)00313-2

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Blood-contact membranes are crucial in almost all extracorporeal blood aphereses and purification procedures. A serious problem they frequently meet is proteins adsorption-caused fouling, which results in a progressive decline in flux and a change of membrane selectivity. Besides, such adsorption can be followed not only by the activation of different defense systems in blood, such as coagulation, complement and fibrinolysis, but also by the adhesion and activation of blood cells. This article reviews studies on the mechanism, affecting factors, and controlling strategies associated with protein adsorption. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：3 / 18

页数：16

共 114 条

[1] COATINGS REDUCE THE FOULING OF MICROFILTRATION MEMBRANES [J].