The IBD process along four chromosomes

被引：27

作者：

Thompson, E. A. ^{[1
]}

机构：

[1] Univ Washington, Dept Stat, Seattle, WA 98195 USA

来源：

THEORETICAL POPULATION BIOLOGY | 2008年 / 73卷 / 03期

关键词：

identity by descent; continuous genome; multiple gene identities; Ewens sampling formula; linkage disequilibrium;

D O I：

10.1016/j.tpb.2007.11.011

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

In this note, we present the continuous-time Markov rate matrix that models identity by descent (ibd) patterns among four chromosomes in a population. The equilibrium distribution of this Markov process along a chromosome is the set of 4-gene state probabilities given by the Ewens sampling formula. This model will facilitate inference of identity by descent among the four chromosomes of a pair of individuals, using data at dense SNP loci among which there may be linkage disequilibrium. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：369 / 373

页数：5

共 18 条

[1] Handling marker-marker linkage disequilibrium: Pedigree analysis with clustered markers [J].