In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes

被引：15
作者：
Morozov, Alexander G. [1 ]
Razborov, Danila A. [1 ]
Egiazaryan, Tatevik A. [1 ]
Baten'kin, Maxim A. [1 ]
Aleynik, Diana Ya. [2 ]
Egorikhina, Marfa N. [2 ]
Rubtsova, Yulia P. [2 ]
Charikova, Irina N. [2 ]
Chesnokov, Sergei A. [1 ]
Fedushkin, Igor L. [1 ]
机构：
[1] Russian Acad Sci, GA Razuvaev Inst Organometall Chem, Nizhnii Novgorod 603950, Russia
[2] Privolzhsky Res Med Univ, Minist Hlth Care Russian Federat, Nizhnii Novgorod 603005, Russia
来源：
JOURNAL OF POLYMERS AND THE ENVIRONMENT | 2020年 / 28卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
Lactide; Ring-opening polymerization; Alkali-earth metal complexes; Polylactic acid; Hydrolytic degradation; Cytotoxicity; Cell adhesion; Biocompatibility; RING-OPENING POLYMERIZATION; EARTH-METAL-COMPLEXES; POLY(LACTIC ACID); LACTIC-ACID; ENZYMATIC-HYDROLYSIS; OXIDE NANOPARTICLES; PROLIFERATION; CERIUM; BIODEGRADATION; MAGNESIUM;
D O I：
10.1007/s10924-020-01803-x
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
An atactic poly-d,l-lactide (PLA) is obtained via ring-opening polymerization (ROP) of lactide stereoisomers mixture catalyzed by the magnesium and calcium acenaphthylenebisamido complexes. The polymer is characterized by gel-permeation chromatography, NMR spectroscopy, and mass spectrometry. The hydrolytic degradation behavior, cytotoxicity, and cell adhesion of the resulting PLA are evaluated. The polymer degrades in phosphate-buffered saline, releasing water-soluble low molecular products that significantly influence dermal fibroblast growth. Polymer demonstrates no cytotoxicity that, along with cell adhesion and their high proliferative activity toward the PLA obtained, proves its biocompatibility.
引用
收藏
页码：2652 / 2660
页数：9
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