In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes

被引：15
作者：
Morozov, Alexander G. [1 ]
Razborov, Danila A. [1 ]
Egiazaryan, Tatevik A. [1 ]
Baten'kin, Maxim A. [1 ]
Aleynik, Diana Ya. [2 ]
Egorikhina, Marfa N. [2 ]
Rubtsova, Yulia P. [2 ]
Charikova, Irina N. [2 ]
Chesnokov, Sergei A. [1 ]
Fedushkin, Igor L. [1 ]
机构：
[1] Russian Acad Sci, GA Razuvaev Inst Organometall Chem, Nizhnii Novgorod 603950, Russia
[2] Privolzhsky Res Med Univ, Minist Hlth Care Russian Federat, Nizhnii Novgorod 603005, Russia
来源：
JOURNAL OF POLYMERS AND THE ENVIRONMENT | 2020年 / 28卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
Lactide; Ring-opening polymerization; Alkali-earth metal complexes; Polylactic acid; Hydrolytic degradation; Cytotoxicity; Cell adhesion; Biocompatibility; RING-OPENING POLYMERIZATION; EARTH-METAL-COMPLEXES; POLY(LACTIC ACID); LACTIC-ACID; ENZYMATIC-HYDROLYSIS; OXIDE NANOPARTICLES; PROLIFERATION; CERIUM; BIODEGRADATION; MAGNESIUM;
D O I：
10.1007/s10924-020-01803-x
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
An atactic poly-d,l-lactide (PLA) is obtained via ring-opening polymerization (ROP) of lactide stereoisomers mixture catalyzed by the magnesium and calcium acenaphthylenebisamido complexes. The polymer is characterized by gel-permeation chromatography, NMR spectroscopy, and mass spectrometry. The hydrolytic degradation behavior, cytotoxicity, and cell adhesion of the resulting PLA are evaluated. The polymer degrades in phosphate-buffered saline, releasing water-soluble low molecular products that significantly influence dermal fibroblast growth. Polymer demonstrates no cytotoxicity that, along with cell adhesion and their high proliferative activity toward the PLA obtained, proves its biocompatibility.
引用
收藏
页码：2652 / 2660
页数：9
相关论文
共 50 条
  • [31] The effect of surface modification of TiMg composite on the in-vitro degradation response, cell survival, adhesion, and proliferation
    Ibrahim, Ahmed Mohamed Hassan
    Takacova, Martina
    Jelenska, Lenka
    Csaderova, Lucia
    Balog, Martin
    Kopacek, Juraj
    Svastova, Eliska
    Krizik, Peter
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2021, 127
  • [32] In vitro cell-transforming potential of secondary polyethylene terephthalate and polylactic acid nanoplastics
    Domenech, Josefa
    Villacorta, Aliro
    Ferrer, Juan Francisco
    Llorens-Chiralt, Raquel
    Marcos, Ricard
    Hernandez, Alba
    Catalan, Julia
    JOURNAL OF HAZARDOUS MATERIALS, 2024, 469
  • [33] Degradation Behavior In Vitro of Carbon Nanotubes (CNTs)/Poly(lactic acid) (PLA) Composite Suture
    Liu, Shuqiang
    Wu, Gaihong
    Chen, Xiaogang
    Zhang, Xiaofang
    Yu, Juanjuan
    Liu, Mingfang
    Zhang, Yao
    Wang, Peng
    POLYMERS, 2019, 11 (06)
  • [34] Assessment of orthodontic biomaterials' cytotoxicity: an in vitro study on cell culture
    Sodor, Alina
    Ogodescu, Alexandru Simion
    Petreus, Tudor
    Sisu, Alina Maria
    Zetu, Irina Nicoleta
    ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 2015, 56 (03) : 1119 - 1125
  • [35] A STUDY ON THE IN-VITRO DEGRADATION OF POLY(LACTIC ACID)
    MIGLIARESI, C
    FAMBRI, L
    COHN, D
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1994, 5 (06) : 591 - 606
  • [36] The microstructure, degradation behavior and cytotoxicity effect of Mg-Sn-Zn alloys in vitro tests
    Ercetin, Ali
    Ozsgun, Ozgur
    Aslantas, Kubilay
    Aykutoglu, Gurkan
    SN APPLIED SCIENCES, 2020, 2 (02):
  • [37] Mechanical and in vitro degradation behavior of magnesium-bioactive glass composites prepared by SPS for biomedical applications
    Dutta, Sourav
    Devi, K. Bavya
    Gupta, Sanjay
    Kundu, Biswanath
    Balla, Vamsi Krishna
    Roy, Mangal
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2019, 107 (02) : 352 - 365
  • [38] Cytotoxicity Assessment of Metal and 3D Printed Resin Orthodontic Attachments An in vitro cell culture behavior study
    Nagib, Riham
    Zogorean, Roxana
    Gavriliuc, Oana Isabella
    Szuhanek, Camelia
    Moldoveanu, Bogdan
    Negrutiu, Meda Lavinia
    Sinescu, Cosmin
    Paunescu, Virgil
    Brad, Silviu
    REVISTA DE CHIMIE, 2018, 69 (06): : 1515 - 1518
  • [39] Study of Elastic Behavior of Polylactic Acid with Yanchama Fibers Composite Simulated as Elastic Orthotropic Material
    Torrente-Prato, Gabriel
    Daza-Gutierrez, Maria
    Pataquiva-Mateus, Alis
    Morales-Arias, Juan P.
    JOURNAL OF NATURAL FIBERS, 2022, 19 (13) : 5741 - 5754
  • [40] Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study
    Sedush, Nikita G.
    Kalinin, Kirill T.
    Azarkevich, Pavel N.
    Gorskaya, Antonina A.
    Hano, Christophe
    COSMETICS, 2023, 10 (04)
12345