Iodine-catalyzed three-component one-pot synthesis of naphthopyranopyrimidines under solvent-free conditions

被引：45

作者：

Kumar, K. Praveen ^{[1
]}

Satyanarayana, S. ^{[1
]}

Reddy, P. Lakshmi ^{[1
]}

Narasimhulu, G. ^{[1
]}

Ravirala, Narender ^{[1
]}

Reddy, B. V. Subba ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 14期

关键词：

3CC Reaction; Molecular iodine; Naphthopyranopyrimidine; NPSR antagonists; MOLECULAR-IODINE; EFFICIENT SYNTHESIS; 4-COMPONENT REACTION; FACILE SYNTHESIS; DERIVATIVES; CONDENSATION; REAGENT; AMINES;

D O I：

10.1016/j.tetlet.2012.01.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iodine is found to be a highly efficient catalyst for the three-component coupling (3CC) of aldehydes, beta-naphthol, and 1,3-dimethylbarbituric acid under solvent-free conditions to afford the corresponding 8,10-dimethyl-12-aryl-12H-naphtho[1',2'5,6]pyrano[2,3-d]pyrimidine-9,11-diones in good yields with high selectivity. The use of readily available iodine makes this method very simple, convenient, and cost-effective. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1738 / 1741

页数：4

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