The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma

被引：22
作者：
Spann, Kirsten [1 ]
Snape, Natale [2 ]
Baturcam, Engin [2 ]
Fantino, Emmanuelle [2 ]
机构：
[1] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia
[2] Univ Queensland, Childrens Hlth Res Ctr, Brisbane, Qld 4072, Australia
来源：
ANNALS OF GLOBAL HEALTH | 2016年 / 82卷 / 01期
关键词：
asthma; allergens; air pollution; virus; epithelium; early life; airway remodeling; immunity; RESPIRATORY SYNCYTIAL VIRUS; DIESEL EXHAUST PARTICLES; EPIDERMAL-GROWTH-FACTOR; SMOOTH-MUSCLE; LUNG-FUNCTION; OXIDATIVE STRESS; TOBACCO-SMOKE; EXTRACELLULAR-MATRIX; PARTICULATE MATTER; CIGARETTE-SMOKING;
D O I：
10.1016/j.aogh.2016.01.007
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The airway epithelium is both a physical barrier protecting the airways from environmental insults and a significant component of the innate immune response. There is growing evidence that exposure of the airway epithelium to environmental insults in early life may lead to permanent changes in structure and function that underlie the development of asthma. Here we review the current published evidence concerning the link between asthma and epithelial damage within the airways and identify gaps in knowledge for future studies.
引用
收藏
页码：28 / 40
页数：13
相关论文
共 134 条
  • [1] Mitochondrial Dysfunction Increases Allergic Airway Inflammation
    Aguilera-Aguirre, Leopoldo
    Bacsi, Attila
    Saavedra-Molina, Alfredo
    Kurosky, Alexander
    Sur, Sanjiv
    Boldogh, Istvan
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (08) : 5379 - 5387
  • [2] Smoke Extract Impairs Adenosine Wound Healing Implications of Smoke-Generated Reactive Oxygen Species
    Allen-Gipson, Diane S.
    Zimmerman, Matthew C.
    Zhang, Hui
    Castellanos, Glenda
    O'Malley, Jennifer K.
    Alvarez-Ramirez, Horacio
    Kharbanda, Kusum
    Sisson, Joseph H.
    Wyatt, Todd A.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013, 48 (05) : 665 - 673
  • [3] Cockroach extract antigen increases bronchial airway epithelial permeability
    Antony, AB
    Tepper, RS
    Mohammed, KA
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (04) : 589 - 595
  • [4] Determinants of asthma after severe respiratory syncytial virus bronchiolitis
    Bacharier, Leonard B.
    Cohen, Rebecca
    Schweiger, Toni
    Yin-DeClue, Huiquing
    Christie, Chandrika
    Zheng, Jie
    Schechtman, Kenneth B.
    Strunk, Robert C.
    Castro, Mario
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (01) : 91 - +
  • [5] Impact of environmental tobacco smoke and active tobacco smoking on the development and outcomes of asthma and rhinitis
    Baena-Cagnani, Carlos E.
    Maximiliano Gomez, R.
    Baena-Cagnani, Rodrigo
    Canonica, G. Walter
    [J]. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 9 (02) : 136 - 140
  • [6] Bagaitkar Juhi, 2008, Tob Induc Dis, V4, P12, DOI 10.1186/1617-9625-4-12
  • [7] Allergy and asthma: Effects of the exposure to particulate matter and biological allergens
    Baldacci, S.
    Maio, S.
    Cerrai, S.
    Sarno, G.
    Baiz, N.
    Simoni, M.
    Annesi-Maesano, I.
    Viegi, G.
    [J]. RESPIRATORY MEDICINE, 2015, 109 (09) : 1089 - 1104
  • [8] Identification of human metapneumovirus-induced gene networks in airway epithelial cells by microarray analysis
    Bao, X.
    Sinha, M.
    Liu, T.
    Hong, C.
    Luxon, B. A.
    Garofalo, R. P.
    Casola, A.
    [J]. VIROLOGY, 2008, 374 (01) : 114 - 127
  • [9] Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren
    Barraza-Villarreal, Albino
    Sunyer, Jordi
    Hernandez-Cadena, Leticia
    Consuelo Escamilla-Nunez, Maria
    Jose Sienra-Monge, Juan
    Ramirez-Aguilar, Matiana
    Cortez-Lugo, Marlene
    Holguin, Fernando
    Diaz-Sanchez, David
    Olin, Anna Carin
    Romieu, Isabelle
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2008, 116 (06) : 832 - 838
  • [10] Cigarette smoke suppresses type I interferon-mediated antiviral immunity in lung fibroblast and epithelial cells
    Bauer, Carla M. T.
    Dewitte-Orr, Stephanie J.
    Hornby, Kyle R.
    Zavitz, Caleb C. J.
    Lichty, Brian D.
    Staempfli, Martin R.
    Mossman, Karen L.
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2008, 28 (03) : 167 - 179
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