The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma

被引：22

作者：

Spann, Kirsten ^{[1
]}

Snape, Natale ^{[2
]}

Baturcam, Engin ^{[2
]}

Fantino, Emmanuelle ^{[2
]}

机构：

[1] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia

[2] Univ Queensland, Childrens Hlth Res Ctr, Brisbane, Qld 4072, Australia

来源：

ANNALS OF GLOBAL HEALTH | 2016年 / 82卷 / 01期

关键词：

asthma; allergens; air pollution; virus; epithelium; early life; airway remodeling; immunity; RESPIRATORY SYNCYTIAL VIRUS; DIESEL EXHAUST PARTICLES; EPIDERMAL-GROWTH-FACTOR; SMOOTH-MUSCLE; LUNG-FUNCTION; OXIDATIVE STRESS; TOBACCO-SMOKE; EXTRACELLULAR-MATRIX; PARTICULATE MATTER; CIGARETTE-SMOKING;

D O I：

10.1016/j.aogh.2016.01.007

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The airway epithelium is both a physical barrier protecting the airways from environmental insults and a significant component of the innate immune response. There is growing evidence that exposure of the airway epithelium to environmental insults in early life may lead to permanent changes in structure and function that underlie the development of asthma. Here we review the current published evidence concerning the link between asthma and epithelial damage within the airways and identify gaps in knowledge for future studies.

引用

页码：28 / 40

页数：13

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