An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

被引：32

作者：

Fu, Rongzhan ^{[1
]}

Jeon, Kyungeun ^{[1
]}

Jung, Cheulhee ^{[1
]}

Park, Hyun Gyu ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Program BK21, Taejon 305701, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 35期

关键词：

SINGLE-STRANDED-DNA; SELECTION INVITRO; NANOPARTICLES; APTAMERS; LIGANDS; SENSOR;

D O I：

10.1039/c1cc13122b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.

引用

页码：9876 / 9878

页数：3