Outcomes after neoadjuvant or adjuvant chemotherapy for cT2-4N0-1 non-small cell lung cancer: A propensity-matched analysis
被引:32
作者:
Brandt, Whitney S.
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Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Brandt, Whitney S.
[1
]
Yan, Wanpu
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Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Yan, Wanpu
[1
]
Zhou, Jian
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Zhou, Jian
[1
]
Tan, Kay See
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Tan, Kay See
[2
]
Montecalvo, Joseph
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Montecalvo, Joseph
[3
]
Park, Bernard J.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Park, Bernard J.
[1
]
Adusumilli, Prasad S.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Adusumilli, Prasad S.
[1
]
Huang, James
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Huang, James
[1
]
Bott, Matthew J.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Bott, Matthew J.
[1
]
Rusch, Valerie W.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Rusch, Valerie W.
[1
]
Molena, Daniela
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Molena, Daniela
[1
]
Travis, William D.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Travis, William D.
[3
]
Kris, Mark G.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Oncol Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Kris, Mark G.
[4
]
Chaft, Jamie E.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Oncol Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Chaft, Jamie E.
[4
]
Jones, David R.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
Jones, David R.
[1
]
机构:
[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Surg Serv, 1275 York Ave, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA
[4] Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Oncol Serv, 1275 York Ave, New York, NY 10021 USA
Objective: Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non-small cell lung cancer has not been extensively studied. Methods: Patients with cT2-4N0-1M0 non-small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan-Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching. Results: In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response. Conclusions: Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non-small cell lung cancer who undergo complete surgical resection.
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Brandt, Whitney S.
;
Bouabdallah, Ilies
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Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Bouabdallah, Ilies
;
Tan, Kay See
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Biostat, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Tan, Kay See
;
Park, Bernard J.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Park, Bernard J.
;
Adusumilli, Prasad S.
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Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Adusumilli, Prasad S.
;
Molena, Daniela
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Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Molena, Daniela
;
Bains, Manjit S.
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Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Bains, Manjit S.
;
Huang, James
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h-index: 0
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Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Huang, James
;
Isbell, James M.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Isbell, James M.
;
Bott, Matthew J.
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h-index: 0
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Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Bott, Matthew J.
;
Jones, David R.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Chaft, Jamie E.
;
Dunphy, Mark
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h-index: 0
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Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Dunphy, Mark
;
Naidoo, Jarushka
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Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Naidoo, Jarushka
;
Travis, William D.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Travis, William D.
;
Hellmann, Matthew
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Hellmann, Matthew
;
Woo, Kaitlin
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Woo, Kaitlin
;
Downey, Robert
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h-index: 0
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Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Downey, Robert
;
Rusch, Valerie
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Rusch, Valerie
;
Ginsberg, Michelle S.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Ginsberg, Michelle S.
;
Azzoli, Christopher G.
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Azzoli, Christopher G.
;
Kris, Mark G.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Brandt, Whitney S.
;
Bouabdallah, Ilies
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Bouabdallah, Ilies
;
Tan, Kay See
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Biostat, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Tan, Kay See
;
Park, Bernard J.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Park, Bernard J.
;
Adusumilli, Prasad S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Adusumilli, Prasad S.
;
Molena, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Molena, Daniela
;
Bains, Manjit S.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Bains, Manjit S.
;
Huang, James
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Huang, James
;
Isbell, James M.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Isbell, James M.
;
Bott, Matthew J.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
Bott, Matthew J.
;
Jones, David R.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Thorac Surg Serv, 1275 York Ave,Box 7, New York, NY 10065 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Chaft, Jamie E.
;
Dunphy, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Dunphy, Mark
;
Naidoo, Jarushka
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Naidoo, Jarushka
;
Travis, William D.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Travis, William D.
;
Hellmann, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Hellmann, Matthew
;
Woo, Kaitlin
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Woo, Kaitlin
;
Downey, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Downey, Robert
;
Rusch, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Rusch, Valerie
;
Ginsberg, Michelle S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Ginsberg, Michelle S.
;
Azzoli, Christopher G.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Azzoli, Christopher G.
;
Kris, Mark G.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA