Timing of allogeneic stem cell transplantation for myelodysplastic syndromes and aplastic anemia

被引:8
|
作者
Cutler, Corey [1 ]
机构
[1] Harvard Univ, Dana Farber Canc Inst, Sch Med, Boston, MA 02215 USA
关键词
MARROW-TRANSPLANTATION; DECISION-ANALYSIS; OLDER PATIENTS; AZACITIDINE; FLUDARABINE; MDS; AGE; ALEMTUZUMAB; REGIMENS; LEUKEMIA;
D O I
10.1182/asheducation-2014.1.77
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
Allogeneic hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) is a potentially curative procedure, but is associated with a significant risk of morbidity and mortality. With the recent approval of disease-modifying agents, the appropriate timing of allogeneic HSCT needs to be addressed. Similarly, the optimal use of these disease-modifying agents before HSCT needs to be determined. In severe aplastic anemia, HSCT is a proven cure, but HLA-matched sibling donors are found in fewer than 25% of newly diagnosed patients. The use of early unrelated donor HSCT is an evolving concept that will become more accepted as improvements in HSCT outcomes continue.
引用
收藏
页码:77 / 81
页数:5
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