Timing of allogeneic stem cell transplantation for myelodysplastic syndromes and aplastic anemia

被引：8

作者：

Cutler, Corey ^{[1
]}

机构：

[1] Harvard Univ, Dana Farber Canc Inst, Sch Med, Boston, MA 02215 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2014年

关键词：

MARROW-TRANSPLANTATION; DECISION-ANALYSIS; OLDER PATIENTS; AZACITIDINE; FLUDARABINE; MDS; AGE; ALEMTUZUMAB; REGIMENS; LEUKEMIA;

D O I：

10.1182/asheducation-2014.1.77

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Allogeneic hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) is a potentially curative procedure, but is associated with a significant risk of morbidity and mortality. With the recent approval of disease-modifying agents, the appropriate timing of allogeneic HSCT needs to be addressed. Similarly, the optimal use of these disease-modifying agents before HSCT needs to be determined. In severe aplastic anemia, HSCT is a proven cure, but HLA-matched sibling donors are found in fewer than 25% of newly diagnosed patients. The use of early unrelated donor HSCT is an evolving concept that will become more accepted as improvements in HSCT outcomes continue.

引用

页码：77 / 81

页数：5

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