Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation

被引：37

作者：

Zhang, Yanmin ^{[1
]}

He, Langchong ^{[1
]}

Meng, Liang ^{[1
]}

Luo, Wenjuan ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Med, Xian 710061, Peoples R China

来源：

VASCULAR PHARMACOLOGY | 2008年 / 48卷 / 2-3期

关键词：

angiogenesis; cell membrane chromatography; taspine; chicken chorioallantoic membrane; HUVEC;

D O I：

10.1016/j.vph.2008.01.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to investigate an anti-angiogenic effect of taspine isolated from Radix et Rhizoma Leonticsi. Taspine was screened for the first time, using cell membrane chromatography (CMC). The anti-angiogeneic activity of taspine was tested by using the chicken chorioallantoic membrane (CAM) neovascularisation model in vivo and the HUVEC proliferation and migration models in vitro, respectively. The results showed that taspine could inhibit CAM angiogenesis significantly within the concentration range of 0.5-2 mu g/egg, proliferation and migration of endothelial cells in a dose-dependent manner. The CAM histomorphology results indicated that taspine could inhibit blood vessels sprouts and proliferation of vascular endothelial cell. These findings suggest that taspine is a promising candidate for use as an angiogenesis inhibitor. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：129 / 137

页数：9

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