Limonoids from Meliaceae with Lipid Peroxidation Inhibitory Activity

被引：0

作者：

Fowles, Robert G. ^{[2
]}

Mootoo, Baldwin S. ^{[1
]}

Ramsewak, Russel S. ^{[1
]}

Reynolds, William F. ^{[3
]}

Nair, Muraleedharan G. G. ^{[4
,5
]}

机构：

[1] Univ W Indies, Dept Chem, St Augustine, Trinidad Tobago

[2] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

[4] Michigan State Univ, Dept Hort, E Lansing, MI 48824 USA

[5] Michigan State Univ, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA

来源：

NATURAL PRODUCT COMMUNICATIONS | 2011年 / 6卷 / 06期

关键词：

Antioxidants; Lipid peroxidation; natural limonoids; semi-synthetic analogues; bicyclononalides; Meliaceae; SWIETENIA-MAHAGONI JACQ; CITRUS LIMONOIDS; CONSTITUENTS; SEEDS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semi-synthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6 % inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semi-synthetic analogues 10 (98.3 %), 16-17, 21-22 and 25 (100 %), which were more active than the positive controls BHA (91.3 %) and TBHQ (95.7 %).

引用

页码：785 / 787

页数：3

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