Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

被引：41

作者：

Abdollahzadeh, Rasoul ^{[1
]}

Shushizadeh, Mohammad Hossein ^{[2
]}

Barazandehrokh, Mina ^{[3
]}

Choopani, Sepideh ^{[4
]}

Azarnezhad, Asaad ^{[5
]}

Paknahad, Sahereh ^{[1
]}

Pirhoushiaran, Maryam ^{[1
]}

Makani, S. Zahra ^{[6
]}

Yeganeh, Razieh Zarifian ^{[1
]}

Al-Kateb, Ahmed ^{[7
]}

Heidarzadehpilehrood, Roozbeh ^{[8
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Pasteur Med Lab, Ahvaz, Iran

[3] Islamic Azad Univ IAUPS, Fac Adv Sci & Technol, Pharmaceut Sci Branch, Tehran, Iran

[4] Islamic Azad Univ, Tehran Med Sci, Tehran, Iran

[5] Kurdistan Univ Med Sci, Res Inst Hlth Dev, Liver & Digest Res Ctr, Sanandaj, Iran

[6] Babol Razi Pathol & Genet Lab, Babol, Iran

[7] Univ Tehran Med Sci, Dept Med Genet, Fac Med, Tehran, Iran

[8] Univ Putra Malaysia, Dept Obstet Gynaecol, Fac Med & Hlth Sci, Seri Kembangan, Malaysia

来源：

INFECTION GENETICS AND EVOLUTION | 2021年 / 96卷

关键词：

COVID-19; Vitamin D receptor; Single nucleotide polymorphisms (SNPs); Genetic predisposition; Clinical outcomes; ACUTE LUNG INJURY; D DEFICIENCY; MULTIPLE-SCLEROSIS; VDR POLYMORPHISMS; D METABOLITES; RISK; CONSEQUENCES; CORONAVIRUS; POPULATION; PREVALENCE;

D O I：

10.1016/j.meegid.2021.105098

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Growing evidence documented the critical impacts of vitamin D (VD) in the prognosis of COVID-19 patients. The functions of VD are dependent on the vitamin D receptor (VDR) in the VD/VDR signaling pathway. Therefore, we aimed to assess the association of VDR gene polymorphisms with COVID-19 outcomes. Methods: In the present study, eight VDR single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 COVID-19 patients in Iran, including 160 asymptomatic, 250 mild/moderate, and 90 severe/critical cases. The association of these polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR). Results: Interestingly, significant associations were disclosed for some of the SNP-related alleles and/or genotypes in one or more genetic models with different clinical data in COVID-19 patients. Significant association of VDRSNPs with signs, symptoms, and comorbidities was as follows: ApaI with shortness of breath (P < 0.001) and asthma (P = 0.034) in severe/critical patients (group III); BsmI with chronic renal disease (P = 0.010) in mild/ moderate patients (group II); Tru9I with vomiting (P = 0.031), shortness of breath (P = 0.04), and hypertension (P = 0.030); FokI with fever and hypertension (P = 0.027) in severe/critical patients (group III); CDX2 with shortness of breath (P = 0.022), hypertension (P = 0.036), and diabetes (P = 0.042) in severe/critical patients (group III); EcoRV with diabetes (P < 0.001 and P = 0.045 in mild/moderate patients (group II) and severe/ critical patients (group III), respectively). However, the association of VDR TaqI and BglI polymorphisms with clinical symptoms and comorbidities in COVID-19 patients was not significant. Conclusion: VDR gene polymorphisms might play critical roles in the vulnerability to infection and severity of COVID-19, probably by altering the risk of comorbidities. However, these results require further validation in larger studies with different ethnicities and geographical regions.

引用

页数：24

共 93 条

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