Drug methylation in cancer therapy: lessons from the TPMT polymorphism

被引：86
作者：
Krynetski, E
Evans, WE
机构：
[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA
[2] Univ Tennessee, Memphis, TN 38163 USA
来源：
ONCOGENE | 2003年 / 22卷 / 47期
关键词：
thiopurine S-methyltransferase; pharmacogenetics;
D O I：
10.1038/sj.onc.1206944
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The genetic polymorphism of thiopurine methyltransferase (TPMT) is one of the most developed examples of pharmacogenetics, spanning from molecular genetics to clinical diagnostics for individualizing thiopurine therapy (i.e. azathioprine, mercaptopurine, and thioguanine). Elucidation of the molecular mechanisms and biochemical consequences of TPMT deficiency demonstrates how pharmacogenetic traits can be identified, characterized, and translated to the bedside. Insights gained from studies of the TPMT polymorphism illustrate the potential of pharmacogenomics to optimize cancer therapy by avoiding toxic side effects in genetically distinct subgroups of patients.
引用
收藏
页码：7403 / 7413
页数：11
相关论文
共 92 条
[1]   6-METHYLTHIOGUANYLIC ACID, A METABOLITE OF 6-THIOGUANINE [J].
ALLAN, PW ;
BENNETT, LL .
BIOCHEMICAL PHARMACOLOGY, 1971, 20 (04) :847-+
[2]  
Alves S, 1999, PHARMACOGENETICS, V9, P257
[3]   Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity [J].
Alves, S ;
Amorim, A ;
Ferreira, F ;
Prata, MJ .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 70 (02) :165-174
[4]   Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia [J].
Ando, M ;
Ando, Y ;
Hasegawa, Y ;
Sekido, Y ;
Shimokata, K ;
Horibe, K .
PHARMACOGENETICS, 2001, 11 (03) :269-273
[5]  
Bemi V, 1999, INT J CANCER, V82, P556, DOI 10.1002/(SICI)1097-0215(19990812)82:4<556::AID-IJC14>3.0.CO
[6]  
2-Y
[7]   Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine [J].
Black, AJ ;
McLeod, HL ;
Capell, HA ;
Powrie, RH ;
Matowe, LK ;
Pritchard, SC ;
Collie-Duguid, ESR ;
Reid, DM .
ANNALS OF INTERNAL MEDICINE, 1998, 129 (09) :716-718
[8]   Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene [J].
Brouwer, C ;
Marinaki, A ;
Lambooy, L ;
Duley, J ;
Shobowale-Bakre, M ;
De Abreu, RA .
LEUKEMIA, 2001, 15 (11) :1792-1793
[9]   Transport of cyclic nucleotides and estradiol 17-β-D-glueuronide by multidrug resistance protein 4 -: Resistance to 6-mercaptopurine and 6-thioguanine [J].
Chen, ZS ;
Lee, K ;
Kruh, GD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33747-33754
[10]   Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy [J].
Colombel, JF ;
Ferrari, N ;
Debuysere, H ;
Marteau, P ;
Gendre, JP ;
Bonaz, B ;
Soulé, JC ;
Modgliani, R ;
Touze, Y ;
Catala, P ;
Libersa, C ;
Broly, F .
GASTROENTEROLOGY, 2000, 118 (06) :1025-1030
12345678910