Antiproliferative Effects of Saponins from the Roots of Platycodon grandiflorum on Cultured Human Tumor Cells

被引：51

作者：

Choi, Yeon Hee ^{[1
,2
]}

Yoo, Dae Seok ^{[1
]}

Cha, Mi-Ran ^{[1
]}

Choi, Chun Whan ^{[1
]}

Kim, Young Sup ^{[1
]}

Choi, Sang-Un ^{[1
]}

Lee, Kang Ro ^{[2
]}

Ryu, Shi Yong ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Taejon 305343, South Korea

[2] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 11期

关键词：

TRITERPENOID SAPONINS; ACTIVATION; EXTRACT;

D O I：

10.1021/np100496p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D-2 (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.

引用

页码：1863 / 1867

页数：5

共 29 条

[1] Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-KB activation in RAW 264.7 cells [J].

Ahn, KS ;

Noh, EJ ;

Zhao, HL ;

Jung, SH ;

Kang, SS ;

Kim, YS .

LIFE SCIENCES, 2005, 76 (20) :2315-2328

[2] Platycodin D and 2"-o-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus [J].

Choi, Jung Hoon ;

Yoo, Ki-Yeon ;

Park, Ok Kyu ;

Lee, Choong Hyun ;

Won, Moo-Ho ;

Hwang, In Koo ;

Ryu, Shi Yong ;

Kim, Young Sup ;

Yi, Jae-Seon ;

Bae, Young-Soo ;

Kang, Il-Jun .

BRAIN RESEARCH, 2009, 1279 :197-208

[3] Establishment of doxorubicin-resistant subline derived from HCT15 human colorectal cancer cells [J].

Choi, SU ;

Kim, NY ;

Choi, EJ ;

Kim, KH ;

Lee, CO .

ARCHIVES OF PHARMACAL RESEARCH, 1996, 19 (05) :342-347

[4] Ameliorating effect of balloon flower saponin on the ethanol-induced memory impairment in mice [J].

Choi, Yeon Hee ;

Kim, Young Sup ;

Yeo, Su Jeong ;

Roh, Seong Hwan ;

Jeong, Young Chul ;

Kang, Jong Seong ;

Ryu, Shi Yong .

PHYTOTHERAPY RESEARCH, 2008, 22 (07) :973-976

[5] Platyconic Acid A, a Genuine Triterpenoid Saponin from the Roots of Platycodon grandiflorum [J].

Choi, Yeon Hee ;

Yoo, Dae Seok ;

Choi, Chun Whan ;

Cha, Mi-Ran ;

Kim, Young Sup ;

Lee, Hyun Sun ;

Lee, Kang Ro ;

Ryu, Shi Yong .

MOLECULES, 2008, 13 (11) :2871-2879

[6] New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum [J].

Fu, Wen-Wei ;

Shimizu, Noriko ;

Takeda, Tadahiro ;

Dou, De-Qiang ;

Chen, Baohui ;

Pei, Yue-Hu ;

Chen, Ying-Jie .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (09) :1285-1287

[7] Studies on the chemical constituents from the roots of Platycodon grandiflorum [J].

Fu, Wen-Wei ;

Dou, De-Qiang ;

Shimizu, Noriko ;

Takeda, Tadahiro ;

Pei, Yue-Hu ;

Chen, Ying-Jie .

JOURNAL OF NATURAL MEDICINES, 2006, 60 (01) :68-72

[8] Five new triterpenoid saponins from the roots of Platycodon grandiflorum [J].

Fu, WW ;

Shimizu, N ;

Dou, DQ ;

Takeda, T ;

Fu, R ;

Pei, YH ;

Chen, YJ .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (04) :557-560

[9]

HARA S, 1987, CHEM PHARM BULL, V35, P501

[10] New triterpenoid saponins from the roots of Platycodon grandiflorum [J].

He, ZD ;

Qiao, CF ;

Han, QB ;

Wang, Y ;

Ye, WC ;

Xu, HX .

TETRAHEDRON, 2005, 61 (08) :2211-2215

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