Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility

被引：47
作者：
Bruggeman, Joost P. [1 ,2 ]
Bettinger, Christopher J. [1 ,3 ]
Langer, Robert [1 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] Erasmus Univ, Erasmus Med Ctr, Dept Plast & Reconstruct Surg, NL-3015 GE Rotterdam, Netherlands
[3] Charles Stark Draper Lab, Ctr Biomed Engn, Cambridge, MA 02139 USA
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2010年 / 95A卷 / 01期
关键词：
biomaterial; elastomer; biocompatibility; degradation; poly(xylitol sebacate); xylitol; GLASS-TRANSITION TEMPERATURE; THIN POLYMER-FILMS; DRUG-DELIVERY; DEGRADATION; SEBACATE);
D O I：
10.1002/jbm.a.32733
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 95A: 92-104, 2010.
引用
收藏
页码：92 / 104
页数：13
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