Acid-initiated stereospecific polymerization of isocyanopeptides

被引：29

作者：

Metselaar, GA ^{[1
]}

Cornelissen, JJLM ^{[1
]}

Rowan, AE ^{[1
]}

Nolte, RJM ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Organ Chem, Inst Mol & Mat, NL-6525 ED Nijmegen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期

关键词：

helical structures; isocyanides; polymerization; stereoselectivity; supramolecular chemistry;

D O I：

10.1002/anie.200462417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recognition with a twist: The acid-initiated polymerization of dipeptide-derived isocyanides (see scheme) is found to be an exceptionally stereospecific process that requires a helical template. The reaction is very sensitive to the acid concentration. At high acid concentrations, the template is destroyed and a competing cyclization reaction becomes predominant. (Chemical Equation Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1990 / 1993

页数：4

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