One Autopsy Proved Neocortical Lewy Body Disease Without the Involvement of the Olfactory Bulb and Brainstem

被引：1

作者：

Chung, Eun Joo ^{[1
,2
,3
]}

Cho, Hwa Jin ^{[1
,4
]}

Hur, Dae Young ^{[1
,5
]}

Kim, Yeong Seok ^{[1
,5
]}

Lee, Kyung-Hwa ^{[6
,7
]}

Kim, Sang Jin ^{[1
,2
,3
]}

机构：

[1] Inje Univ, Busan Paik Hosp Brain Bank, Busan, South Korea

[2] Inje Univ, Dementia & Neurodegenerat Dis Res Ctr, Busan, South Korea

[3] Inje Univ, Busan Paik Hosp, Dept Neurol, Coll Med, 75 Bokji Ro, Busan 47392, South Korea

[4] Inje Univ, Busan Paik Hosp, Dept Pathol, Coll Med, Busan, South Korea

[5] Inje Univ, Dept Anat, Coll Med, Busan, South Korea

[6] Chonnam Natl Univ Hosp Brain Bank, Gwangju, South Korea

[7] Chonnam Natl Univ, Dept Pathol, BioMed Sci Grad Program BMSGP, Hwasun Hosp & Med Sch, Hwasun, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2022年 / 37卷 / 23期

关键词：

Incidental Lewy Body Disease; Parkinson Disease; Lewy Body Dementia; Lewy Bodies; Lewy Neurites; Synucleinopathies; ALPHA-SYNUCLEIN PATHOLOGY; DEMENTIA; BODIES; DIAGNOSIS; DLB; GUIDELINES; MANAGEMENT; UBIQUITIN; RELEVANCE;

D O I：

10.3346/jkms.2022.37.e195

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lewy bodies (LBs) and Lewy neurites (LNs) are pathological hallmarks of Parkinson's disease (PD) or dementia with LBs (DLB). Incidental Lewy body disease (iLBD) is defined when LBs and LNs are found in the brain of normal elderly individuals. A 65-year-old man presented with autopsy-proven Lewy body pathology (LBP). He had never complained of cognitive impairments or parkinsonian motor symptoms, and he had always maintained independence in activities of daily living. Hypopigmentations in the locus coeruleus and substantia nigra were discovered during the autopsy. The patient showed severe-to-extremely severe LBs in the neocortex and limbic areas, except in the nucleus basalis of Meynert, amygdala, and brainstem, according to microscopic findings. Hence, using several of the previously known staging systems, it was difficult to classify the patient's LBP type. Furthermore, these findings were unique because they had never been observed before in iLBD.

引用

页数：7

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